Kinematic Zenith Tropospheric Delay Estimation with GNSS PPP in Mountainous Areas.

The use of global navigation satellite systems (GNSS) precise point positioning (PPP) to estimate zenith tropospheric delay (ZTD) profiles in kinematic vehicular mode in mountainous areas is investigated. Car-mounted multi-constellation GNSS receivers are employed. The Natural Resources Canada Canadian Spatial Reference System PPP (CSRS-PPP) online service that currently processes dual-frequency global positioning system (GPS) and Global'naya Navigatsionnaya Sputnikovaya Sistema (GLONASS) measurements and is now capable of GPS integer ambiguity resolution is used.

Design, construction and application of a fully automated equimolar peptide mixture synthesizer.

A fully automated peptide synthesizer has been constructed that is capable of the synthesis of equimolar peptide mixtures and the simultaneous synthesis of 36 individual peptides. The synthesizer was constructed from a workstation of our own design utilizing a Zymark robot arm. A Macintosh II computer coordinates the movements of the robotic arm, the switching of over 40 solenoid valves and the monitoring of sensors in the workstation.

Peptoids: a modular approach to drug discovery.

Peptoids, oligomers of N-substituted glycines, are described as a motif for the generation of chemically diverse libraries of novel molecules. Ramachandran-type plots were calculated and indicate a greater diversity of conformational states available for peptoids than for peptides. The monomers incorporate t-butyl-based side-chain and 9-fluorenylmethoxy-carbonyl alpha-amine protection.

Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis.

A fully automated peptide synthesizer has been constructed that is capable of the simultaneous synthesis of up to 36 individual peptides and the synthesis of equimolar peptide mixtures. The instrument consists of an array of reaction vessels, a series of solenoid valves to control liquid flow, and a Zymark robot to deliver solvents and reagents; all components are computer controlled and coordinated. Equimolar peptide mixtures are obtained by algorithms that automate the mixing and distribution of peptide-resin particles.