The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm.

Myelodysplastic Neoplasm (MDS) is a cancer associated with aging, often leading to acute myeloid leukemia (AML). One of its hallmarks is hypermethylation, particularly in genes responsible for DNA repair. This study aimed to evaluate the methylation and mutation status of DNA repair genes (single-strand - XPA, XPC, XPG, CSA, CSB and double-strand - ATM, BRCA1, BRCA2, LIG4, RAD51) in MDS across three patient cohorts (Cohort A-56, Cohort B-100, Cohort C-76), using methods like pyrosequencing, real-time PCR, immunohistochemistry, and mutation screening.

Associations of a metal mixture and vitamin D with sleep duration among adolescents and young adults from the 2011-2018 NHANES cycles.

Introduction: Heavy metal exposure has been associated with poor sleep, but little is known about the cumulative associations of multiple metals with sleep duration, particularly among adolescents. This study examined the association of blood lead (Pb), cadmium (Cd), and mercury (Hg) concentrations with sleep duration and possible effect modification by vitamin D.

Methods: The study sample consisted of 16-25-year-olds (n = 2637) from the 2011-2018 National Health and Nutrition Examination Survey.

Evaluation of the evidence-based practices for the management of PCOS in the Latin America context: the consensus of the Latin American Association of Gynecological Endocrinology (ALEG).

Objectives: Polycystic Ovary Syndrome (PCOS) is a complex condition affecting approximately 1 in 10 women of reproductive age. However, limited data are available regarding the specific characteristics and needs of women with PCOS in Latin America. This consensus sought to evaluate the evidence-based practices for the management of PCOS for Latin American populations, consolidate regional insights, identify eventual gaps in implementation and identify key research opportunities.

Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against in Endodontic Infections.

This study aims to evaluate the efficacy of curcumin (CUR), a natural polyphenol with potent antimicrobial and anti-inflammatory properties, when formulated as solid lipid nanoparticles (CUR-loaded SLN) against . Solid lipid nanoparticles (SLNs) were prepared as a carrier for CUR, which significantly improved its solubility. SLNs made with cetyl palmitate and Tween 80 were obtained via the hot ultrasonication method.

Investigating the Detachment of Glazed Ceramic Tiles Used in Buildings: A Brazilian Case Study.

Ceramic detachments in cladding systems are indicative of adhesion loss between the ceramic tiles and the substrate or its adhesive mortar due to inadequate quality workmanship, the quality of the adhesive mortar or that of the ceramic material, whether acting simultaneously or not. The shear stresses resulting from the ceramic tiles' expansion due to humidity accelerate this process. There is a shortage of studies on the quality of ceramic tiles and adhesive mortars.