Publications by authors named "S C A Meijvis"
Importance: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease, but their systematic underrepresentation in cardiovascular randomized clinical trials (RCTs) limits the generation of appropriate evidence to guide cardiovascular risk management (CVRM).
Objective: To evaluate the underrepresentation of patients with CKD in cardiovascular RCTs, and to highlight evidence gaps in CVRM medications in this population.
Evidence Review: A systematic search was conducted in ClinicalTrials.
Background: Patients with chronic kidney disease (CKD) require a personalised strategy for cardiovascular risk management (CVRM) to reduce their high risk of cardiovascular morbidity and mortality. Despite their high risk, patients with CKD appear to be underrepresented in randomised controlled trials (RCTs) for pharmacological CVRM interventions to reduce cardiovascular risk (pharmacological CVRM interventions). As a result, it remains unclear whether the efficacy of these interventions found in patients without CKD is similarly applicable to patients with CKD.
View Article and Find Full Text PDFHypertension is an important risk factor for cardiovascular disease. In the Netherlands, there are approximately 2.8 million people with hypertension.
View Article and Find Full Text PDFBackground: Central venous catheters (CVC) remain a commonly used vascular access option in haemodialysis, despite guidelines advising to preferably use arteriovenous fistulae. Compared to younger patients, the risk-benefit ratio of CVC in older patients might be more beneficial, but previous studies mainly focussed on catheter-related bacteraemia and/or assessed tunnelled CVC (TCVC) only. This study's aim was to compare all catheter-related infections and malfunctions in older patients with younger patients using all CVC subtypes.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of different lock solutions (taurolidine and citrate) in preventing infection and malfunction of central venous catheters (CVCs) in hemodialysis patients.
- A total of 1514 patients were analyzed, revealing that taurolidine-based solutions significantly reduced the need for CVC removal due to infection or malfunction compared to citrate-based solutions.
- Although taurolidine showed better results, the study's retrospective nature means its findings should be interpreted carefully, and no definitive conclusions about the superiority of one solution over another can be made.