Publications by authors named "S Bussolati"
The porcine corpus luteum as a model for studying the effects of nanoplastics.
Environ Toxicol Pharmacol
September 2024
Article Synopsis
- Nanoplastics (NPs) treatment impacts fertility by affecting the proliferation of luteal and endothelial cells differently, with increased proliferation in luteal cells but unchanged proliferation in endothelial cells.
- NPs treatment was associated with increased ATP levels in endothelial cells and higher levels of reactive oxygen species in both cell types, indicating oxidative stress.
- The findings suggest that NPs could hinder progesterone production and alter growth factors, highlighting potential fertility risks related to NPs exposure.
Background: This study aimed to investigate variations of the oxidative status in cats affected by urethral obstruction (UO) under Feline Idiopathic Cystitis (FIC) and Bacterial Cystitis (BC), in comparison with a group of healthy subjects. In both groups, the levels of several markers (either direct or indirect) indicative of the oxidative attack and of the antioxidant response were analyzed on plasma and urine samples. In particular, the plasma samples were evaluated for nitric oxide (NO), hydroperoxides derived by reactive oxygen activity (d-ROMs test), superoxide anion (O), glutathione peroxidase activity (GPx), superoxide dismutase activity (SOD), and ferric reducing antioxidant power (FRAP test); while on urine the levels of NO, d-ROMs, FRAP, SOD, malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were measured.
View Article and Find Full Text PDFAre the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures.
Environ Toxicol Pharmacol
March 2024
Phthalates are plasticizing chemicals, widely used in packaging materials and consumer products for several decades. These molecules have raised concerns because of their toxicity and their use have been restricted in several countries. Therefore, novel phthalates have been introduced.
View Article and Find Full Text PDFNanoplastics induced oxidative stress and VEGF production in aortic endothelial cells.
Environ Toxicol Pharmacol
November 2023
Article Synopsis
- The study focuses on the environmental impacts of nanoplastics (NPs), highlighting their interference with reproductive and adipose stromal cells and potential cardiovascular risks.
- Researchers investigated how NPs affect aortic endothelial cells (AOC) by measuring their interaction with these cells, cell growth, and oxidative stress responses.
- Findings showed that NPs significantly increase metabolic activity and Vascular Endothelial Growth Factor (VEGF) production in AOC, while also disrupting the redox status, indicating a negative impact on normal cell function.
PFOA is mainly employed in products with water and oil repellent properties. Due to its persistence, bioaccumulation and critical effects on health, its use has been restricted in several countries. This research was intended to explore PFOA action on the main functions of swine ovarian granulosa cells, a valuable model for translational medicine.
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