Publications by authors named "S Burgaz"

Article Synopsis
  • VCE-003.2, a derivative of cannabigerol, shows neuroprotective effects in Parkinson's disease models linked to mitochondrial dysfunction and neuroinflammation, now being tested against protein dysregulation associated with the disease.
  • Researchers administered an adeno-associated viral vector carrying a mutated α-synuclein gene to mice, causing motor impairments and neuron loss, then treated them with VCE-003.2 to assess its effects.
  • Results indicated that VCE-003.2 significantly improved motor performance, preserved neuron integrity, reduced microglia and astrocyte activation in the brain, and influenced gene expression related to immune responses, expanding its potential therapeutic benefits in Parkinson's disease.
View Article and Find Full Text PDF

Hairdressers are constantly occupationally exposed to many chemicals have the potential to cause allergies and carcinogenic effects, act as skin and eye irritants and induce oxidative stress and DNA damage. This study aimed to evaluate occupation-induced genotoxicity based on the presence of micronucleus (MN) and other nuclear anomalies in urothelial cells and measure oxidative DNA damage based on the 8-hydroxy-2'-deoxyguanosine level in the urine of Turkish hairdressers. Originality of this study comes from that there was no study on MN and other nuclear anomalies frequencies and oxidative DNA damage in urine samples of hairdressers in the literature.

View Article and Find Full Text PDF
Article Synopsis
  • A study in Central Anatolia, Turkey, investigated the health effects of arsenic (As) in drinking water among residents, comparing those exposed to higher levels (>50 μg L) with unexposed individuals (<10 μg L).
  • Findings showed that residents' arsenic intake was significant, with higher concentrations found in urine and hair samples of the exposed group, indicating effective metabolism of arsenic without saturation.
  • Despite these findings, no major increase in skin lesions was noted in the exposed group, though a correlation was found between higher hair arsenic levels and keratosis, highlighting the need for further long-term health studies in the region.
View Article and Find Full Text PDF
Article Synopsis
  • Cannabinoids, especially through CB receptors and GPR55, have shown neuroprotective effects in preclinical models of neurodegenerative diseases, sparking significant research interest.
  • The study tested a compound called VCE-006.1, which acts on GPR55, and found it effective in reversing motor defects and neuron loss in models of Parkinson's disease, although it had limited effects on inflammatory reactions.
  • Despite showing some protective benefits in models of neurodegeneration, the compound did not alter GPR55 expression levels, potentially explaining its varied effectiveness in different experimental setups.
View Article and Find Full Text PDF

In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). To this end, we used mice bearing partial genetic deletion of the BiP gene (BiP mice), which, for the ALS model, were crossed with mutant SOD1 (mSOD1) transgenic mice to generate mSOD1/BiP double mutant mice. Our data revealed a more intense neurological decline in the double mutants, reflected in a greater deterioration of the neurological score and rotarod performance, with also a reduced animal survival, compared to mSOD1 transgenic mice.

View Article and Find Full Text PDF