Publications by authors named "S Bruce"
Background: Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory/immune mechanisms are induced by TSE, play a key role in the recovery process versus development of post-TSE chronic pain, and are sex specific. In this study, we tested the hypothesis that the inflammatory marker C-reactive protein (CRP) is associated with chronic pain after TSE in a sex-specific manner.
View Article and Find Full Text PDFAdults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment. While the underlying cellular and molecular mechanisms are still incompletely understood, ammonium and bile acids (BAs) seem to play a key role in this pathology, by crossing the blood-brain-barrier and modifying neuronal homeostasis and synaptic plasticity. This experimental study aimed to investigate the effects of ammonium and BAs on dendritic spines of rat hippocampal CA1 neurons.
View Article and Find Full Text PDFPossible misdiagnosis of pregnancy-associated stroke in the emergency department.
J Stroke Cerebrovasc Dis
January 2025
Objectives: Pregnancy and the postpartum period are associated with an increased risk of ischemic and hemorrhagic stroke. The incidence of missed or delayed diagnosis of pregnancy-associated stroke (PAS) in the emergency setting is unknown.
Materials And Methods: We conducted a retrospective cohort study of women hospitalized for labor and delivery identified through administrative claims data from all nonfederal EDs and hospitals in 11 states (New York 2006-2017, Florida 2005-2019, 3 states from 2016-2020, 6 states from 2016-2019).
Social Buffering of PTSD: Longitudinal Effects and Neural Mediators.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Article Synopsis
- This study investigates how early social support after trauma affects PTSD symptoms over time and explores specific brain regions involved in this process, such as the amygdala and ventromedial prefrontal cortex.
- Using data from 315 participants in the AURORA study, researchers measured PTSD symptoms and perceived emotional support at multiple time points, while also conducting neuroimaging two weeks post-trauma.
- The results show that early emotional support is linked to changes in white matter connectivity between key brain areas, but it also highlighted unexpected increased threat reactivity in the default mode network, suggesting complex neural pathways in response to social threats.
Article Synopsis
- - The study explored the use of wrist-wearable devices to track heart rate variability (HRV) as potential biomarkers for recovery from adverse neuropsychiatric effects following traumatic events, specifically in a socioeconomically disadvantaged group.
- - Researchers monitored participants within 72 hours of a traumatic event and over a course of 6 months, validating HRV characteristics linked to various posttraumatic symptoms, such as pain, re-experiencing, and anxiety.
- - The findings indicate that changes in HRV could effectively predict improvements or worsening in symptoms, suggesting that these wearable technologies could serve as useful screening tools for identifying posttraumatic stress in high-risk populations.