Publications by authors named "S Browall"
is a close relative of the major human pathogen It is increasingly associated with lower-respiratory-tract infections (LRTI) and a high prevalence of antimicrobial resistance (AMR). is difficult to identify using traditional typing methods due to similarities with and other members of the mitis group (SMG). Using whole-genome sequencing of LRTI isolates and a comparative genomic approach, we found that a large number of pneumococcal virulence and colonization genes are present in the core genome.
View Article and Find Full Text PDFThe effects of pneumococcal conjugated vaccines (PCVs) need to be investigated. In Stockholm County, Sweden, PCV7 was introduced in the childhood immunisation programme in 2007 and changed to PCV13 in 2010.Over 90% of all invasive isolates during 2005-2014 (n=2336) and carriage isolates, 260 before and 647 after vaccine introduction, were characterised by serotyping, molecular typing and antibiotic susceptibility, and serotype diversity was calculated.
View Article and Find Full Text PDFPneumococcal conjugated vaccines (PCVs) have shown protection against invasive pneumococcal disease by vaccine serotypes, but an increase in non-vaccine serotype disease has been observed. Type-specific effects on clinical manifestation need to be explored. Clinical data from 2096 adults and 192 children with invasive pneumococcal disease were correlated to pneumococcal molecular serotypes.
View Article and Find Full Text PDFArticle Synopsis
- Streptococcus pneumoniae serotype 3 has a special covering (capsule) and can cause really serious diseases with high death rates.
- Scientists studied the DNA of many strains and found most were similar but some had different genetic changes over time.
- They looked at two related bacteria from a sick patient and discovered they behaved differently in tests and reacted differently to medicine, showing that tiny changes in their genes can lead to important differences in how they act.
Background: Pneumococcal serotypes are represented by a varying number of clonal lineages with different genetic contents, potentially affecting invasiveness. However, genetic variation within the same genetic lineage may be larger than anticipated.
Methods: A total of 715 invasive and carriage isolates from children in the same region and during the same period were compared using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing.