Publications by authors named "S Bringer-Deutsch"
Study Question: Should we perform oocyte accumulation to preserve fertility in women with Turner syndrome (TS)?
Summary Answer: The oocyte cryopreservation strategy is not well adapted for all TS women as their combination of high basal FSH with low basal AMH and low percentage of 46,XX cells in the karyotype significantly reduces the chances of freezing sufficient mature oocytes for fertility preservation.
What Is Known Already: An oocyte cryopreservation strategy requiring numerous stimulation cycles is needed to preserve fertility in TS women, to compensate for the low ovarian response, the possible oocyte genetic alterations, the reduced endometrial receptivity, and the increased rate of miscarriage, observed in this specific population. The validation of reliable predictive biomarkers of ovarian response to hormonal stimulation in TS patients is necessary to help practitioners and patients choose the best-personalized fertility preservation strategy.
Article Synopsis
- The study investigates how hematopoietic stem cell transplantation (HSCT) affects uterus size in women who survived childhood acute leukemia, focusing on the age at HSCT and conditioning type.
- Conducted at 13 French university hospitals, the prospective cohort study included 88 female HSCT survivors compared to a control group, using MRI to measure uterine volume.
- Results showed a significant reduction in uterine volume among HSCT survivors, with those receiving total body irradiation experiencing a 75.3% decrease, compared to a 43.1% decrease in those who received an alkylating agent-based regimen.
Article Synopsis
- Low serum progesterone on frozen embryo transfer day in hormone replacement therapy is linked to poorer reproductive outcomes, prompting a study on "rescue protocols" to improve results.
- The study compared reproductive outcomes in women with low progesterone receiving individualized luteal phase support (iLPS) versus those with adequate levels undergoing pre-implantation genetic testing.
- Results showed a significantly higher ongoing pregnancy rate of 41.03% in the supplemented group compared to 18.60% in the non-supplemented group, indicating the importance of progesterone supplementation for better fertility outcomes.
Article Synopsis
- About 7% of breast cancer cases are diagnosed in women under 40, which raises important questions about fertility preservation options during treatment.* -
- A study of over 15,000 women in France showed that the fertility preservation rate increased to 17% by 2019 but dropped to 13.9% in 2020, with most births occurring through spontaneous pregnancies.* -
- Among women who preserved their fertility, 19.6% had a live birth after treatment compared to only 3.9% in those who did not preserve fertility, indicating significantly better outcomes for the FP group.*
Objective: Five to 7% of breast cancers affect women under 40 years old. The survival of these patients has been improved thanks to therapeutic advances, often to the detriment of their fertility. The objective of this study is to evaluate the activity of oncofertility and the future of young women with breast cancer managed at the Montpellier University Hospital.
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