Publications by authors named "S Brigida"
Wastewater treatment plants (WWTPs) provide optimal conditions for the environmental spread of . As part of the Evaluation of Sanitary Risk Related to the Discharge of Wastewater to the Ground (SCA.Re.
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- The study investigates how maternal infection with SARS-CoV-2 affects immune responses in the placenta and its implications for fetal brain development, particularly focusing on Hofbauer cells (HBCs), which act as fetal placental macrophages.
- Researchers analyzed HBCs from term placentas of pregnant individuals who tested positive or negative for SARS-CoV-2, finding notable differences in gene expression and impaired functions like phagocytosis in certain HBC subpopulations.
- The findings indicate that HBCs can be transformed into microglia-like cells, allowing for personalized models to study microglial programming in children affected by maternal SARS-CoV-2 infection.
Pathogenic microorganisms released onto the soil from point or diffuse sources represent a public health concern. They can be transported by rainwater that infiltrates into subsoil and reach the groundwater where they can survive for a long time and contaminate drinking water sources. As part of the SCA.
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- Maternal infection with SARS-CoV-2 activates immune responses that can adversely affect fetal brain development through fetal brain microglia, which are difficult to study directly.
- Researchers found that Hofbauer cells (HBCs) from pregnancies affected by SARS-CoV-2 show different cellular responses and impaired functions crucial for brain development compared to HBCs from unaffected pregnancies.
- The study suggests that HBCs can be transformed into microglia-like cells, providing a unique opportunity to create personalized models to better understand how maternal infections influence the programming of offspring's brain immune cells.
During the COVID-19 pandemic, wastewater monitoring has been used to monitor the levels of SARS-CoV-2 RNA entering the sewerage system. In Italy, the Istituto Superiore di Sanità coordinated the SARI project (Sorveglianza Ambientale Reflue in Italia) to detect SARS-CoV-2 and its variants. In this study, the concentration of SARS-CoV-2 and its variants in raw wastewater against COVID-19 cases was evaluated together with the effect of temperature and precipitation on virus spread.
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