Publications by authors named "S Brichler"
Article Synopsis
- * It includes data from 413 patients (142 HBV-HDV and 271 HBV monoinfected) and finds that those with HBV-HDV are generally younger and experience a significantly higher incidence of HCC over 5 years compared to HBV-only patients.
- * The results indicate that HDV is an independent risk factor for the development of HCC in patients with cirrhosis, highlighting its important role regardless of HBV
Background: Neutralizing antibodies targeting the SARS-CoV-2 Spike protein reduce COVID-19-related risk of hospitalization, particularly in high-risk individuals. The COCOPREV-R study aimed to evaluate and compare clinical outcomes in high-risk SARS-CoV-2 patients treated with dual monoclonal antibody therapies and to identify associated virological factors.
Methods: The COCOPREV-R study retrospectively collected real-world data from high-risk patients receiving Bamlanivimab/Etesevimab or Casirivimab/Imdevimab dual monoclonal antibody therapies (22 February 2021 to 15 June 2021).
Article Synopsis
- A study conducted in France during the 2023-24 RSV season analyzed the effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV infections in infants, focusing on breakthrough cases.
- Out of 695 RSV-infected infants, researchers sequenced the full-length RSV genome of 545 infants, identifying that 48% had breakthrough infections despite receiving nirsevimab.
- While no resistance was found in RSV-A infections from nirsevimab-treated infants, two cases of RSV-B showed substitutions linked to resistance, indicating a potential concern for the antibody's effectiveness against this variant.
Article Synopsis
- * Out of 230 patients evaluated, TE showed strong diagnostic accuracy for detecting cirrhosis and advanced fibrosis, with area under the receiver operating characteristic curves of 0.88 and 0.86, outperforming other non-invasive tests.
- * The findings suggest that LSM values above 10 kPa indicate a high probability of advanced fibrosis, while values below 6 kPa almost completely rule out significant fibrosis, necessitating further discussion for values between 6 and 10 kPa.