Publications by authors named "S Breaux"
Elucidating the genetic contributions to Parkinson's disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization of potentially disease-causing, protein-altering and splicing mutations in 710 cases and 11,827 controls from genetically predicted African or African admixed ancestries. We explored copy number variants (CNVs) and runs of homozygosity (ROHs) in prioritized early onset and familial cases.
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- Understanding the genetics of Parkinson's disease (PD) is crucial for developing effective treatments globally, but there's a lack of diversity in current research.
- The Black and African American Connections to Parkinson's Disease (BLAAC PD) study aims to investigate the genetics of PD specifically in Black and African American populations, addressing this gap.
- With a goal of enrolling up to 4,000 participants, including both individuals with PD and controls, the study emphasizes community involvement and aims to remove barriers to participation in research.
Wild chimpanzees live in large, mixed-sex groups that display a fission-fusion social organization. To provide a social environment more like that of wild chimpanzees, Chimp Haven integrated smaller groups of 3-4 individuals into one large group of 18 individuals. This large group was introduced to a 20,234.
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- A survey collected data on 1122 chimpanzees from various facilities, focusing on their age, sex, social dynamics, and behaviors observed over two years.
- Tool-use was observed in 94.3% of the chimps, while social grooming, copulation, and nest-building were reported in 85.7%, 68.3%, and 58.9%, respectively, with 45.6% engaging in all four species-typical behaviors.
- Logistic regression analysis revealed that factors like rearing history, group size, and facility type significantly influenced behaviors such as copulation, tool use, nest-building, and social grooming among chimpanzees.