Publications by authors named "S Braet"
Problem: Academic promotion is important for faculty career development and retention in academic medicine. However, the promotion process is time consuming, with little guidance offered to ensure successful outcomes. The authors describe their institution's standardized approach to providing clear and reliable academic promotion support and share associated outcomes.
View Article and Find Full Text PDFSafety of single-dose bedaquiline combined with rifampicin for leprosy post-exposure prophylaxis: A Phase 2 randomized non-inferiority trial in the Comoros Islands.
PLoS Med
October 2024
Article Synopsis
- The World Health Organization recommends the use of single-dose rifampicin (SDR) for leprosy post-exposure prophylaxis (PEP), potentially reducing leprosy risk by about 50% in contacts of patients.
- A Phase 2 trial tested a new PEP regimen that combines bedaquiline with rifampicin (BE-PEP) against the standard therapy (SDR-PEP), focusing on safety and QT interval changes in patients.
- The trial, involving 313 participants, demonstrated that BE-PEP did not significantly differ from SDR-PEP regarding QT interval changes after treatment, indicating comparable safety profiles between the two regimens.
Article Synopsis
- - Anti-mycobacterial drugs can cause QT interval prolongation, risking serious heart issues, but monitoring is tough in places with high rates of leprosy and tuberculosis.
- - The BE-PEOPLE trial assessed the safety of a bedaquiline regimen while measuring QT intervals before and after treatment using both mobile electrocardiogram (mECG) and standard methods.
- - Results showed that mECG is a feasible and accurate tool for QT interval tracking, with a strong correlation to traditional measurements, although automated readings were generally less precise.
The progesterone receptor (PR) belongs to the steroid receptor family of ligand-regulated transcription factors, controlling genes important for development, metabolism, and reproduction. Understanding how diverse ligands bind and modulate PR activity will illuminate the design of ligands that control PR-driven signaling pathways. Here, we use molecular dynamics simulations to investigate how PR dynamics are altered by functionally diverse ligands.
View Article and Find Full Text PDFBackground: Post-exposure prophylaxis (PEP) using single-dose rifampicin reduces progression from infection with Mycobacterium leprae to leprosy disease. We compared effectiveness of different administration modalities, using a higher (20 mg/kg) dose of rifampicin-single double-dose rifampicin (SDDR)-PEP.
Methods: We did a cluster randomised study in 16 villages in Madagascar and 48 villages in Comoros.