[Aplastic anaemia associated with pregnancy].

Aplastic anaemia is rear disease caused by destruction of pluripotent stem cells in bone marrow. Pregnancy is one of the main factor that lead to immunosuppression. During pregnancy aplastic anaemia could be life-threatening for both mother and child, because of the variety of complications like bleeding and infections.

[Unlicensed and off label usage of some drugs in obstetric practice].

Off label usage refer with prescribing of some drugs outside indications licensed by the regulatory organs of the country or is in conflict with the product information. During pregnancy there are cases, when the health of the mother is a priority and the obstetrician has no alternative, except off label using the medication. The examples, which we show, include usage of different drugs in Bulgaria with their unlicensed indications, age group, dosage and duration of the curing course.

[Using ultrogestan for the treatment of spontaneous abortions and complications of climax in women with epilepsy].

Epilepsy is a disease, closely connected with sex-hormones and can lead to adverse repercussion on the reproductive health. The ovarial hormones influence excitation of neurocells membranes and have a lot of effects on brain, leading to provoking epileptic activity. The progesteron decrease and the estrogens increase the brain excitation, that's why estrogens (act like a proconvulsant) are proconvulsant and progesteron is anticonvulsant.

[Carriers of thrombophilic factor among women with preeclampsia (preliminary report)].

The aim of this study was to determine whether inherited thrombophilia increases the risk of mild preeclampsia. Twenty five women who developed mild preeclampsia and 49 controls--women with previous uneventful pregnancies, were tested for factor V Leiden, C677T gene variant of methylenetetrahydrofolate reductase (MTHFR), polymorphism 4G/5G in plasminogen activator inhibitor 1 (PAI 1), polymorphism A1/A2 in platelet glycoprotein IIb/Illa (GIPrllb/llla A1/A2). The higher but not significant prevalence of C677T gene variant and polymorphism A1/A2 in women with preeclampsia compared with controls was found: 32% and 12.

[Rear cases of tubal pregnancy during second trimester--diagnostic and therapeutic problems].

The lack of space abilities predetermine the fate of tubal pregnancy. Very often it disturbs in first few weeks. Preserving the tubal pregnancy after first trimester is very rear and often ends fatal.