Publications by authors named "S Bowrey"
Objectives: Randomised controlled trial of the effect of a perineural infusion of levobupivacaine on moderate/severe phantom limb pain 6 months after major lower limb amputation.
Setting: Single-centre, UK university hospital.
Participants: Ninety patients undergoing above-knee and below-knee amputation for chronic limb threatening ischaemia under general anaesthesia.
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map.
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- A retrospective study of 338 lower limb amputee patients was conducted to identify factors affecting rehabilitation success with prosthetic limbs and resulted in the development of a scoring tool called the BLARt score.
- The tool was validated on 199 patients, showing that a BLARt score of ≥13 indicated a lack of good functional outcomes, with only a few achieving any level of independent walking.
- The BLARt score is a simple and effective tool that could help both patients and clinicians set realistic expectations for walking ability after surgery, highlighting the psychological and physical challenges amputees face during rehabilitation.
Article Synopsis
- Nursing practice should rely on credible evidence, and education should prepare nurses to question practices, critically analyze research, and apply findings to patient care.
- Health professionals engage with patients in clinical trials and contribute to enhancing care through a solid evidence foundation.
- The article discusses research nurses’ responsibilities in clinical trials, focuses on patient safety, and covers regulatory frameworks, consent processes, and ethical standards in clinical research.