Therapeutic management of DRESS: a retrospective study of 38 cases.

Background: There is no consensus regarding treatment for drug reaction with eosinophilia and systemic symptoms (DRESS).

Objectives: We report a single-center observational series of therapeutic management of DRESS.

Methods: We examined data for 50 consecutive patients admitted from March 2005 to June 2009 with a discharge diagnosis of DRESS (RegiSCAR score).

Systemic involvement of acute generalized exanthematous pustulosis: a retrospective study on 58 patients.

Background: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction characterized by rash with sterile pustules, high fever and elevated circulating neutrophil counts.

Objectives: To investigate the frequency and clinical features of AGEP systemic involvement.

Methods: This retrospective study included all patients hospitalized in our department between 2000 and 2010 with a discharge diagnosis of AGEP.

Counselling on sun protection, a survey of French paediatricians.

Background: High sun exposure during childhood is an important risk factor for skin cancers at adulthood. Paediatricians are first in line to provide sun protection (SP) information.

Objective: To describe paediatricians' attitudes towards SP counselling and compare French and American paediatricians' behaviours.

Toxic epidermal necrolysis, DRESS, AGEP: do overlap cases exist?

Background: Severe cutaneous adverse reactions to drugs (SCARs) include acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS) and epidermal necrolysis (Stevens-Johnson syndrome-toxic epidermal necrolysis [SJS-TEN]). Because of the varied initial presentation of such adverse drug reactions, diagnosis may be difficult and suggests overlap among SCARs. Overlapping SCARs are defined as cases fulfilling the criteria for definite or probable diagnosis of at least 2 ADRs according to scoring systems for AGEP, DRESS and SJS-TEN.

Permethrin and malathion resistance in head lice: results of ex vivo and molecular assays.

Background: Treatment of head lice infestation relies on the application of topical insecticides. Overuse of these products has led to the emergence of resistance to pyrethroids and malathion worldwide. Permethrin resistance in head lice is mostly conferred by the knockdown resistance (kdr) trait.