Publications by authors named "S Boule"
Article Synopsis
- * The huR83C mouse model replicates the disease phenotype and has been used to test the effectiveness of BEAM-301, a treatment that utilizes lipid nanoparticles and adenine base editing to correct the harmful G6PC1-R83C variant.
- * BEAM-301 has shown the ability to correct about 60% of the variant in liver cells, restore blood sugar control, improve overall health, and increase survival rates in mice, indicating its potential as a therapeutic option for patients with this specific genetic mutation
Recurrences of Atrial Fibrillation Despite Durable Pulmonary Vein Isolation: The PARTY-PVI Study.
Circ Arrhythm Electrophysiol
March 2023
Background: Recurrences of atrial fibrillation (AF) after pulmonary vein isolation (PVI) are mainly due to pulmonary vein reconnection. However, a growing number of patients have AF recurrences despite durable PVI. The optimal ablative strategy for these patients is unknown.
View Article and Find Full Text PDFThe spectrum of inherited arrhythmogenic diseases (IADs) includes disorders without overt structural abnormalities (i.e. primary inherited arrhythmia syndromes) and structural heart diseases (i.
View Article and Find Full Text PDFImplantable cardiac defibrillator leads dysfunction after LVAD implantation.
Pacing Clin Electrophysiol
November 2020
Article Synopsis
- * Out of 401 patients with an ICD before LVAD, 122 had their ICD checked before and after implantation, with 55% showing significant lead dysfunction, including issues with sensing and pacing.
- * Despite the lead dysfunction observed, it did not result in severe clinical problems, indicating that management of these issues was effective and conservative.