Publications by authors named "S Boukhrissi"
Background And Objectives: Autoimmune encephalitis (AIE) and paraneoplastic neurologic syndromes (PNSs) encompass a heterogeneous group of antibody-associated disorders. Both the number of syndromes and commercially available antibody tests have increased considerably over the past decade. High-quality population-based data on epidemiology of these disorders and real-world performance of antibody tests are needed.
View Article and Find Full Text PDFClinical Relevance of Autoantibodies and Inflammatory Parameters in Non-infectious Scleritis.
Ocul Immunol Inflamm
December 2022
Purpose: Scleritis is a potentially blinding disorder, with highly unpredictable course and outcome. We analyzed the prevalence and clinical relevance of autoantibodies and inflammatory parameters in non-infectious scleritis.
Methods: Retrospective analysis of laboratory findings in all consecutive patients at the department of Ophthalmology of the Erasmus MC with non-infectious scleritis.
Article Synopsis
- The study investigated the clinical characteristics and treatment responses of 56 patients with positive antibodies against glutamic acid decarboxylase 65 (anti-GAD65), focusing on their neurologic symptoms and immunotherapy outcomes.
- Among patients with high concentrations of anti-GAD65 (over 10,000 IU/mL), a majority exhibited classical syndromes like stiff-person syndrome and cerebellar ataxia, showing a 70% improvement rate with immunotherapy, though none achieved complete recovery.
- Patients with low anti-GAD65 concentrations presented a wider variety of symptoms, suggesting the need for alternative diagnostic approaches due to their less typical clinical features.
Article Synopsis
- A study on 32 patients with GABABR antibodies revealed associated cognitive changes, seizures, and a connection to small cell lung carcinoma through the discovery of KCTD16 antibodies.
- Most patients exhibited severe seizures and cognitive issues, with 42% experiencing refractory status epilepticus and some developing rapidly progressive dementia.
- The introduction of KCTD16 antibodies into detection assays improved the sensitivity for identifying GABABR antibodies, indicating a potential link between autoimmune encephalitis and underlying cancer.
Objective: To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2.
Methods: VGKC-positive patients were tested for LGI1 and Caspr2 antibodies. Patients lacking both antibodies were matched (1:2) to VGKC-negative patients.