Publications by authors named "S Bottcher"
Background: Patients with advanced chronic non-malignant conditions often experience significant symptom burden. Therefore, overcoming barriers to interprofessional collaboration between general practitioners (GPs) and specialist palliative home care (SPHC) teams is essential to facilitate the timely integration of palliative care elements. The KOPAL trial aimed to examine the impact of case conferences between GPs and SPHC teams on symptom burden and pain in patients with advanced chronic heart failure, chronic obstructive pulmonary disease, and dementia.
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- Activation of Fas in adipocytes inhibits the browning process, potentially leading to increased body weight gain in mice, and its expression correlates with higher BMI in humans.
- The study found that Fas activation decreases energy expenditure through reduced protein levels of p53, a tumor suppressor, in adipocytes.
- In humans, higher p53 levels in subcutaneous and visceral white adipose tissue were linked to increased BMI, while higher levels in visceral fat were associated with lower insulin sensitivity.
The quantification of submicroscopic minimal residual disease (MRD) after therapy proved to have independent prognostic significance in many mature B-cell malignancies. With the advent of routine benchtop cytometers capable of simultaneously analyzing ≥8 colors and with improved standardization, flow cytometry has become the method of choice for MRD assessments in some lymphoma entities. Herein we describe general aspects of flow cytometric standardization.
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- Wearable biosensors from the wrist can monitor seizures, but poor signal quality affects reliability, making it crucial to understand how seizures impact data quality during different phases.
- The study evaluates the signal quality of various biosignals during different seizure types and examines the effects of peri-ictal movements on data accuracy.
- Findings show that tonic-clonic seizures cause a significant drop in blood volume pulse signal quality and increase accelerometer activity, highlighting the need for improved data assessment methods in seizure monitoring.
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- Non-polio enteroviruses (NPEV) are viruses that can cause serious illness around the world.
- Scientists are studying blood samples to learn about how these viruses have spread in the past and what might happen in the future.
- A recent test with twelve labs showed that there are big differences in how they measure NPEV antibodies, which means we need better standard rules for testing them.