Publications by authors named "S Borte"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFStudy Design: Genome-wide association study (GWAS) meta-analysis with downstream analyses.
Objective: To explore the genetic architecture of chronic low back pain (cLBP) and identify underlying biological mechanisms that contribute to its development.
Summary Of Background Data: Chronic low back pain is prevalent and debilitating, with many cases having no identifiable biological cause.
Objective: To assess the safety, tolerability, and effectiveness of the intravenous immunoglobulin (IVIG) Intratect 50 g/L in immunoglobulin replacement therapy (IgRT) in a prospective, large-scale non-interventional study (NIS). The analysis focused upon patients with secondary immunodeficiency (SID), the most frequent indication for IgRT in this NIS.
Materials And Methods: Patients were enrolled at 123 centers in Germany.
Article Synopsis
- * A genome-wide association meta-analysis of nearly 122,000 ANX cases revealed 58 significant genetic variants and 66 related genes, with many of these findings replicated in a larger independent sample.
- * The findings indicate a substantial genetic overlap between ANX and other conditions like depression, emphasizing GABAergic signaling as a key mechanism, thereby enhancing our understanding of the genetic basis of ANX for future research.
Article Synopsis
- Reduced lymphocyte counts are common during viral infections, including SARS-CoV-2, but the long-term effects on immune balance remain unclear.
- In a study of 106 COVID-19 patients, B lymphocyte subsets showed significantly lower levels in patients compared to healthy controls.
- While differences in immune cells were noted between patients with "Post-COVID-19 Condition" (PCC) and healthy individuals, no specific lasting changes in the immune system were found in PCC compared to those who recovered from COVID-19.