Publications by authors named "S Bonapace"
Aims: Whether the plasma-based ceramide-based risk score CERT1 improves risk prediction for cardiovascular disease (CVD) is uncertain.
Materials And Methods: Baseline and follow-up data were combined from two cohorts, 334 patients with established/suspected CVD and 196 patients with type 2 diabetes followed for a median of 74 months (interquartile range 54-79 months). For the calculation of CERT1 risk score, we measured four specific plasma ceramides [Cer(d18:1/16:0), Cer(d18:1/18:0) and Cer(d18:1/24:1)] and their ratios to Cer(d18:1/24:0).
Background: Studies have reported an association between metabolic dysfunction-associated steatotic liver disease (MASLD) and an increased risk of developing atrial fibrillation (AF). However, the magnitude of the risk and whether this risk varies with the severity of MASLD remains uncertain.
Methods: In this systematic review and meta-analysis, we searched three large electronic databases using predefined keywords to identify cohort studies (published up to 30 September 2024) in which MASLD was diagnosed by liver biopsy, imaging methods, International Classification of Diseases (ICD) codes, or blood-based scores.
Metabolic syndrome (MetS) is not a disease but a constellation of metabolic abnormalities that together increase the risk of developing cardiovascular disease (CVD) [...
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- A study investigated the CERT1 score, a plasma ceramide-based risk assessment tool, to see if it predicts increased risks of death and heart attacks in patients with coronary artery disease (CAD).
- A total of 167 patients were observed over a median period of 6 years; the findings indicated a significant correlation between high pre-stress CERT1 scores and the likelihood of experiencing all-cause mortality or nonfatal heart attacks.
- The association held true even after accounting for other health factors, indicating that both pre-stress and post-stress high-risk CERT1 scores can reliably indicate increased long-term risks in these patients.