Publications by authors named "S Bonacorsi"
Introduction: Systemic sclerosis (SSc) is a connective tissue disease at the interface between inflammation and autoimmunity progressively leading to diffuse microvascular and fibrotic involvement of the skin and of multiple internal organs. Approximately, 20-40% of SSc patients suffer from cutaneous calcinosis, a debilitating manifestation due to calcium salt deposition in soft connective tissues, causing pain, ulceration, infection, and deformities, responsible of severe functional limitations. Pathomechanisms are poorly understood as well as markers/molecules capable to predict the risk of patients to develop calcinosis.
View Article and Find Full Text PDFKingella kingae is a cause of bacteremia, endocarditis, and the leading cause of osteoarticular infections between 6 and 48 months of life. We report on a rare case of K. kingae meningitis in the absence of endocarditis and immune deficiency in a 26-month-old boy emphasizing the distinct genomic determinants of the strain which may be of importance to the pathogenesis of the disease.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on acute bacterial meningitis (ABM) cases in children, specifically analyzing instances without cerebrospinal fluid (CSF) pleocytosis, a condition where CSF has elevated leukocyte counts.
- - Out of 4,754 ABM cases from 2001 to 2022 in France, only 173 (3.6%) lacked CSF pleocytosis, with a significant majority linked to meningococcal infections, and these cases showed a higher mortality rate (18% vs. 6%).
- - The research concluded that while ABM without CSF pleocytosis is rare, it is critical, especially for children who experience seizures before hospital admission, suggesting that increased meningoc
Tularemia in Pediatric Patients: A Case Series and Review of the Literature.
Pediatr Infect Dis J
September 2024
Article Synopsis
- Tularemia is often misdiagnosed in children due to its similar symptoms to other common lymphadenopathy diseases, leading to delayed treatment; awareness among pediatricians is crucial.
- A review of 94 cases revealed a wide age range of affected children, with infection sources primarily from zoonotic transmission and contaminated water, and fever being a common symptom.
- Effective treatment typically includes aminoglycosides, fluoroquinolones, or tetracyclines, and pediatricians should consider tularemia in cases of febrile lymphadenopathy to avoid unnecessary costs from misguided antibiotic treatments and extended hospital stays.
Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain the extracellular matrix, ensuring the structural role of soft connective tissues; (2) secrete cytokines and growth factors; (3) communicate with each other and with other cell types, acting as signalling source for stem cell niches; and (4) are involved in tissue remodelling, wound healing, fibrosis, and cancer. This review focuses on the developmental heterogeneity of dermal fibroblasts, on their ability to sense changes in biomechanical properties of the surrounding extracellular matrix, and on their role in aging, in skin repair, in pathologic conditions and in tumour development. Moreover, we describe the use of fibroblasts in different models (e.
View Article and Find Full Text PDF