Publications by authors named "S Bolle"
Background: High-risk medulloblastoma (HRMB) is rare in adults. The 5-year overall survival rate is less than 60%. We present here a retrospective analysis of adults treated with an intensive pediatric chemo-radiotherapy regimen PNET HR + 5: NCT00936156.
View Article and Find Full Text PDFRationale for irradiation of persisting oligo-skeletal metastases to improve survival of metastatic neuroblastoma patients with a poor response to chemotherapy: A retrospective study.
Pediatr Blood Cancer
January 2025
Article Synopsis
- Persistent mIBG-positive skeletal metastases after high-dose chemotherapy in high-risk neuroblastoma patients are linked to poor outcomes, prompting an investigation into the effects of irradiation on these metastases.* -
- A retrospective study reviewed 201 patients treated between 2000 and 2020, finding that 15% had persistent skeletal uptake after treatment, with some achieving complete responses, but recurrence was common in areas that were previously affected.* -
- The study suggests that while a minority of patients maintained mIBG positivity post-treatment, managing disease control during therapy remains a significant challenge, complicating efforts to conduct a randomized study on treatment strategies.*
Purpose: Childhood cancer survivors (CCS) have an increased risk of developing late chronic diseases, which can be influenced by the cancer type and its treatment. These chronic diseases can be severe and disabling, typically emerging years to decades after treatment. These deficits negatively impact quality of life, intelligence quotient, and memory.
View Article and Find Full Text PDFPurpose: Supratentorial (ST) ependymoma subgroups are defined by two different fusions with different prognoses. Astroblastomas, MN1-altered, have ependymal-like histopathologic features and represent a differential diagnosis in children. We hypothesized that ZFTA-fused ependymoma and YAP1-fused ependymoma on the one hand, and astroblastoma, MN1-altered, on the other hand, show different MRI characteristics.
View Article and Find Full Text PDFBackground: Children with constitutional mismatch repair deficiency (CMMRD) syndrome have an increased risk of high-grade gliomas (HGG), and brain imaging abnormalities. This study analyzes brain imaging features in CMMRD syndrome children versus those with HGG without CMMRD.
Methods: Retrospective comparative analysis of brain imaging in 30 CMMRD children (20 boys, median age eight years, 22 with HGG), seven with Lynch syndrome (7 HGG), 39 with type 1 neurofibromatosis (NF1) (four with HGG) and 50 with HGG without MMR or NF1 pathogenic variant ("no-predisposition" patients).