Publications by authors named "S Bo"
Background: Microsatellite instability (MSI) significantly impacts treatment response and outcomes in colon cancer; however, its underlying molecular mechanisms remain unclear. This study aimed to identify prognostic biomarkers by comparing MSI and microsatellite stability (MSS).
Methods: Data from the GSE39582 dataset downloaded from the Gene Expression Omnibus database were analyzed for differentially expressed genes (DEGs) and immune cell infiltration between MSI and MSS.
Article Synopsis
- Strong coupling in photonic microstructures shows potential for applications in spectral control and optical sensing.
- The study explores coupling effects in a photonic multilayer featuring a nanocavity on a one-dimensional photonic crystal, with results indicating that the spectral profile can be adjusted by changing the dielectric layer's thickness.
- The research identifies a strong coupling regime with significant Rabi splitting (36 meV) and provides a method for tuning coupling strength by modifying the metallic film's thickness, which has implications for future optical coupling technologies.
Article Synopsis
- There is a growing need for non-invasive methods to monitor glycogen storage diseases (GSD), specifically utilizing saturation transfer (ST) MRI to observe changes in muscle glycogen in a GSD II mouse model.
- The research involved measuring various metabolites in the skeletal muscles of both healthy and GSD II mice at different ages, assessing the accumulation and levels of muscle glycogen and energy metabolites.
- Results showed that while glycogen accumulation increased in younger GSD II mice, it plateaued in adults, indicating potential biomarkers for monitoring disease progression and treatment efficacy in GSDs.
Hypertension is a major global health issue, contributing to significant cardiovascular morbidity and mortality. Mitochondrial dysfunction, particularly through dysregulated mitophagy, has been implicated in the pathogenesis of hypertension. We wanted to find out the relationship between mitochondrial autophagy and changes in arterial smooth muscle cell tension and the molecular mechanism.
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