Publications by authors named "S Blouin"
Article Synopsis
- Hutchison-Gilford progeria syndrome (HGPS) is a genetic disorder caused by a mutation in the LMNA gene, leading to rapid aging and serious health issues, including bone density loss and a shorter life span.
- In studies using Lmna progeria mice, researchers analyzed bone mineralization and found similarities in mineral content across various ages but noted a higher number of empty osteocyte lacunae, indicating bone deterioration.
- The findings highlighted significant reductions in bone volume and abnormal growth plates in Lmna mice, suggesting that bone dysplasia occurs due to problems in bone formation despite normal turnover rates.
The lacunocanalicular network (LCN) is an intricate arrangement of cavities (lacunae) and channels (canaliculi), which permeates the mineralized bone matrix. In its porosity, the LCN accommodates the cell network of osteocytes. These two nested networks are attributed a variety of essential functions including transport, signaling, and mechanosensitivity due to load-induced fluid flow through the LCN.
View Article and Find Full Text PDFOsteocytes are mechanosensitive, bone-embedded cells which are connected via dendrites in a lacuno-canalicular network and regulate bone resorption and formation balance. Alterations in osteocyte lacunar volume, shape and density have been identified in conditions of aging, osteoporosis and osteolytic bone metastasis, indicating patterns of impaired bone remodeling, osteolysis and disease progression. Osteolytic bone disease is a hallmark of the hematologic malignancy multiple myeloma (MM), in which monoclonal plasma cells in the bone marrow disrupt the bone homeostasis and induce excessive resorption at local and distant sites.
View Article and Find Full Text PDFWhite dwarfs are stellar remnants devoid of a nuclear energy source, gradually cooling over billions of years and eventually freezing into a solid state from the inside out. Recently, it was discovered that a population of freezing white dwarfs maintains a constant luminosity for a duration comparable with the age of the universe, signalling the presence of a powerful, yet unknown, energy source that inhibits the cooling. For certain core compositions, the freezing process is predicted to trigger a solid-liquid distillation mechanism, owing to the solid phase being depleted in heavy impurities.
View Article and Find Full Text PDFPurpose: To measure the dislocation forces in relation to haptic material, flange size and needle used.
Setting: Hanusch Hospital, Vienna, Austria.
Design: Laboratory Investigation.