Publications by authors named "S Biscarini"
Article Synopsis
- A cluster of four patients with CRAB, who had never been treated with FDC, showed non-susceptibility to FDC due to a specific mutation in the PirA protein, which included a premature stop codon and amino acid deletion.
- Between March and July 2024, 33 CRAB cases were identified in a single hospital ward, with genetic analysis revealing that four of these cases were closely related variants showing reduced FDC susceptibility.
- The study emphasizes the need for careful testing of FDC susceptibility in patients, as the identified clones suggest possible transmission of resistant strains even in those without prior treatment.
Background: Whether solid organ transplant (SOT) can be safely performed in recipients with ongoing SARS-CoV-2 infection is still a debated question.
Methods: A systematic review of the literature on recipients with ongoing SARS-CoV-2 infection at the time of surgery and the associated outcomes.
Results: From 29 studies, we identified 54 recipients; their median age was 47.
Article Synopsis
- The study focuses on the use of intravenous fosfomycin (IVFOF) for severe infections and potential adverse events (AEs) impacting its use.
- Of the 224 patients analyzed, 42.4% experienced at least one AE, with hypernatremia being the most common, occurring in 23.7% of patients, especially among those in ICU with low respiratory infections and septic shock.
- Therapeutic drug monitoring (TDM) showed some promise in predicting AEs, particularly hypernatremia, indicating that regular monitoring could improve patient safety during IVFOF treatment.
Objectives: Monoclonal antibodies (mAbs) have proven to be a valuable tool against COVID-19, mostly among subjects with risk factors for progression to severe illness. Tixagevimab/cilgavimab (TIX/CIL), a combination of two Fc-modified human monoclonal antibodies, has been recently approved to be employed as early treatment.
Methods: Two groups of immunocompromised patients exposed to different early treatments (i.
Here, we describe a conserved motor neuron-specific long non-coding RNA, Lhx1os, whose knockout in mice produces motor impairment and postnatal reduction of mature motor neurons (MNs). The ER stress-response pathway result specifically altered with the downregulation of factors involved in the unfolded protein response (UPR). Lhx1os was found to bind the ER-associated PDIA3 disulfide isomerase and to affect the expression of the same set of genes controlled by this protein, indicating that the two factors act in conjunction to modulate the UPR.
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