[A new instrument to evaluate the quality of life on patients treated by hemodialysis (IPPE): first exploratory analysis of psychometric properties].

Introduction: The article presents a new instrument for the evaluation the Quality of Life, concerning patients on haemodialysis; IPPE tool has been created to be brief, multidimensional and also capable to considering, into the evaluation of patient Quality of Life, both familiar that hospital relational aspects. The purpose of this report is to explore the factor structure and the internal validity of the IPPE questionnaire.

Methods: The research involved three ASL on the territory of Salerno (57%), Verona (20.

Significance of plasma B-type natriuretic peptide in hemodialysis patients: blood sample timing and comorbidity burden.

Plasma B-type natriuretic peptide (BNP) concentration was evaluated in end-stage renal disease patients to verify if measurements before or after the session could furnish different information. BNP levels in plasma from 52 hemodialysis (HD) patients were measured both before and after the first session of the week. Echocardiographic studies were also performed and patients were followed over a period of 28 months.

PON1 activity and genotype in patients with arterial ischemic stroke and in healthy individuals.

Objective: Paraoxonase-1 (PON1) is an esterase with antioxidant properties. Low PON1 enzyme activity or specific allelic polymorphisms seem to be associated with the risk of developing coronary artery disease or acute ischemic stroke (AIS). Our objective was to determine the distribution of both PON1 enzyme activity and its genotype in a group of patients with AIS.

Paraoxonase activity and paraoxonase 1 gene polymorphism in patients with uremia.

Patients on hemodialysis (HD) show an increased risk for developing atherothrombotic events. The oxidative modification of low density lipoproteins (LDL) play an important role in the pathogenesis of atherosclerosis. In patients with uremia (chronic renal failure and HD), the increased oxidative stress induces oxidative modification of LDL.

HDL3-related decreased serum paraoxonase (PON) activity in uremic patients: comparison with the PON1 allele polymorphism.

Background: Patients with chronic renal failure on maintenance haemodialysis (HD) are at high risk of atherothrombotic events; an enhanced oxidant stress might have a major role. The decrease of human paraoxonase (PON1), an anti-oxidant high-density lipoprotein (HDL)-linked enzyme, is a possible mechanism for developing cardiovascular disease. To ascertain the causes of low PON1 in such patients, we investigated the contribution of both PON1 gene polymorphism and individual pattern of HDL.