Publications by authors named "S Bhaskaran"
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective properties, was tested at two doses (150 mg/kg and 300 mg/kg) at onset and late-stage disease. Results demonstrated a significant delay in disease progression at both doses, with treated mice showing a slower advance to early disease stages compared to untreated controls.
View Article and Find Full Text PDFOne of the most critical factors impacting healthspan in the elderly is the loss of muscle mass and function, clinically referred to as sarcopenia. Muscle atrophy and weakness lead to loss of mobility, increased risk of injury, metabolic changes and loss of independence. Thus, defining the underlying mechanisms of sarcopenia is imperative to enable the development of effective interventions to preserve muscle function and quality in the elderly and improve healthspan.
View Article and Find Full Text PDFBilateral medullary syndrome (BMS) is an extremely rare and devastating neurological disorder resulting from ischemia or infarction of the medulla oblongata. This case report presents two unique instances of BMS, both leading to fatal outcomes. Case 1 describes a 70-year-old male with a history of systemic hypertension who presented with limb weakness, slurred speech, and dysphagia.
View Article and Find Full Text PDFArticle Synopsis
- - Granulomatosis with polyangiitis (GPA) is a rare autoimmune condition affecting small to medium-sized blood vessels, mostly in the respiratory system and kidneys, and can exceptionally cause pachymeningitis, a rare inflammation of the brain's protective membranes.
- - A case report discusses a 55-year-old woman whose GPA presented initially as pachymeningitis, with symptoms like ear pain, hoarseness, and difficulty swallowing due to lower cranial nerve involvement.
- - Diagnosis was confirmed through MRI imaging and specific antibody tests, and treatment included corticosteroids and other immunosuppressants, leading to significant improvement, emphasizing the need for early diagnosis and adherence to treatment to prevent relapses.
Purpose: This study aimed to analyze the clinical presentation, treatment outcomes, and histopathology features of ocular surface squamous neoplasia (OSSN) in a South Indian population and correlate the area of lesions to the histopathological grade/severity of carcinoma in situ (CIN) and squamous cell carcinoma (SqCC) invasive and noninvasive tumors.
Methods: The study was a retrospective cross-sectional study. The study reviewed electronic medical records (EMRs) of 99 eyes of 99 South Indian patients who underwent en bloc excision and biopsy for tumors in the corneal and conjunctival epithelium with suspicion of OSSN over 1 year from January 2019 to December 2019.