CLOCK gene 3'UTR and exon 9 polymorphisms show a strong association with essential hypertension in a North Indian population.

Background: Hypertension (HTN) is a medical condition characterized by persistent systolic and diastolic blood pressures of ≥ 140 mmHg and ≥ 90 mmHg, respectively. With more than 1200 million adult patients aged 30-79 years worldwide according to the latest WHO data, HTN is a major health risk factor; more importantly, 46% of patients are unaware of this condition. Essential hypertension (EH), also known as primary hypertension, is the predominant subtype and has a complex etiology that involves both genetic and non-genetic factors.

Analysis of hair styling wax residues on human hair: A forensic investigation with ATR-FTIR spectroscopy and chemometric interpretation.

A comparative analysis of hair evidence recovered from the crime scene and the hair of suspects or victims is common in the forensic scenario. However, its evidentiary value increases with cosmetic applications like gel, wax, spray, or other hair treatments. Therefore, after extracting these products from hair strands, they can link the victim and accused to the crime scene and with each other, serving as corroborative evidence.

Surface Immobilization of Oxidized Carboxymethyl Cellulose on Polyurethane for Sustained Drug Delivery.

Polyurethane (PU) has a diverse array of customized physical, chemical, mechanical, and structural characteristics, rendering it a superb option for biomedical applications. The current study involves modifying the polyurethane surface by the process of aminolysis (aminolyzed polyurethane; PU-A), followed by covalently immobilizing Carboxymethyl cellulose (CMC) polymer utilizing Schiff base chemistry. Oxidation of CMC periodically leads to the creation of dialdehyde groups along the CMC chain.

Molecular Characterization and Analysis of Risk Factors Associated with Brucellosis in Central Indian and Meghalaya Population.

In this study we evaluated the utility of Abortus Melitensis Ovis Suis Brucella PCR (AMOS PCR) for the molecular characterization of Brucella species and analyzed the associated risk factors for brucellosis in Central Indian and Meghalayan population. AMOS PCR was carried out in a total of 160 BSCP-31 PCR-positive DNA samples isolated previously from the blood of Central Indian ( = 90) and Meghalayan cohorts ( = 70). Clinical and associated risk factors recorded earlier were used to establish strain-specific disease outcomes in study cohorts.

Temperature projections and heatwave attribution scenarios over India: A systematic review.

The average global temperature is rising due to anthropogenic emissions. Hence, a systematic approach was used to examine the projected impacts of rising global temperatures on heatwaves in India and provide insights into mitigation and adaptation strategies. With over 24,000 deaths attributed to heatwaves from 1992 to 2015, there is an urgent need to understand India's vulnerabilities and prepare adaptive strategies under various emission scenarios.