Chitosan-based hydrogel system for efficient removal of Cu[II] and sustainable utilization of spent adsorbent as a catalyst for environmental applications.

The growing requirement for clean potable water requires sustainable methods of eliminating heavy metal ions and other organic contaminants. Herein, we synthesized a novel dual-purpose magnetically separable chitosan-based hydrogel system (CSGO-R@IO) that can efficiently remove toxic Cu pollutants from water. FT-IR, XRD, SEM-EDX, VSM, XPS analyses were used to characterize the synthesized hydrogel.

Assessment of key regulatory genes and identification of possible drug targets for Leprosy (Hansen's disease) using network-based approach.

Leprosy is a major health concern and continues to be a source of fear and stigma among people worldwide. Despite remarkable achievements in the treatment, understanding of pathogenesis and transmission, epidemiology of leprosy still remains inadequate. The prolonged incubation period, slow rates of occurrence in those exposed and deceptive clinical presentation pose challenges to develop reliable strategies to stop transmission.

Towards enhancement of fungal hydrolytic enzyme cocktail using waste algal biomass of Oscillatoria obscura and enzyme stability investigation under the influence of iron oxide nanoparticles.

Development of low-cost and economic cellulase production is among the key challenges due to its broad industrial applications. One of the main topics of research pertaining to sustainable biomass waste based biorefinaries is the development of economic cellulase production strategies. The main cause of the increase in cellulase production costs is the use of commercial substrates; as a result, the cost of any cellulase-based bioprocess can be decreased by employing a productive, low-cost substrate.

NADP/H binding nearly doubles the stability of a drug target: an unfolding study.

Aspartate beta semialdehyde dehydrogenase (ASADH) was studied using various spectroscopic techniques and size exclusion chromatography to examine the unfolding of free (apo) and NADP/H-bound (holo) forms of ASADH. Non-cooperative guanidinium chloride (GdnHCl)-induced unfolding of the apo ASADH was discovered, and no partially folded intermediate structures were stabilized. On the other hand, it was observed that GdnHCl's unfolding of holoenzyme was a cooperative process without any stable intermediate structure.

Assessing extent of single stranded DNA damage in oral mucosal cells of patients with oral squamous cell carcinoma and its correlation with TNM staging.

Context: This study was carried out on the assumption that oral mucosal cells might show DNA damage in oral squamous cell carcinoma (OSCC).

Aims: To evaluate the extent of DNA damage in oral smears of patients with OSCC and determine correlation if any of the extent of DNA damage to TNM staging of oral cancer.

Settings And Design: A randomized controlled study at a regional cancer centre was designed for this project.