Publications by authors named "S Bhagani"
Article Synopsis
- The study assessed bone mineral density (BMD) in older HIV-positive individuals in Kenya as they enrolled in a clinical trial, focusing on participants aged 60 and above.
- A total of 296 Black African participants were included, with findings indicating a high prevalence of osteoporosis (37.5%) and osteopenia (47.3%) among them, alongside calculated fracture risks.
- The research highlighted challenges in diagnosing osteoporosis due to limited access to dual-energy x-ray absorptiometry (DXA) in Kenya, showing a negative correlation between fracture risk probabilities and femoral neck BMD.
Objectives: The survival rate of people with HIV admitted to intensive care units (ICUs) is approaching that of people without HIV. We conducted a matched-cohort study of people with and without HIV admitted to ICU at a large hospital to compare short-term mortality, during 2000-2019.
Methods: People with HIV were matched to people without HIV (1:2) on age, sex, admission year and Acute Physiology and Chronic Health Evaluation (APACHE)-II score.
Article Synopsis
- Biomarker guided therapy can enhance treatment for COVID-19 patients, with a focus on evaluating the effectiveness of point-of-care (POC) antibody tests in this context.* -
- Two POC tests, LumiraDX and RightSign, were assessed for their reliability and ease of use against a standard test, with both showing moderate agreement but differing in accuracy and usability.* -
- The RightSign test was found to be easier to use and more effective at identifying patients without antibodies compared to the LumiraDX test, despite both tests being associated with clinical outcomes.*
Objectives: People with HIV are at increased risk for metabolic dysfunction-associated steatohepatitis (MASH). Although sex differences are documented in the general population, their role in the context of HIV is less understood.
Methods: This was a multicentre cohort study including people with HIV without viral hepatitis coinfection.
Background And Aims: HBV and HIV coinfection is a common occurrence globally, with significant morbidity and mortality. Both viruses lead to immune dysregulation including changes in natural killer (NK) cells, a key component of antiviral defense and a promising target for HBV cure strategies. Here we used high-throughput single-cell analysis to explore the immune cell landscape in people with HBV mono-infection and HIV/HBV coinfection, on antiviral therapy, with emphasis on identifying the distinctive characteristics of NK cell subsets that can be therapeutically harnessed.
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