Dissecting the Cell-Killing Mechanisms of Hydroxyurea Using Spot Assays.

Hydroxyurea is an inhibitor of ribonucleotide reductase and is commonly used in laboratories to induce replication stress or arrest cells in the S phase for cell cycle or checkpoint studies. However, hydroxyurea also causes side effects such as oxidative stress, particularly under chronic exposure conditions. This complicates the interpretation of the cell-killing mechanisms, particularly in a previously uncharacterized mutant, and thus hampers the analyses.

Weakly supervised learning for subcutaneous edema segmentation of abdominal CT using pseudo-labels and multi-stage nnU-Nets.

Volumetric assessment of edema due to anasarca can help monitor the progression of diseases such as kidney, liver or heart failure. The ability to measure edema non-invasively by automatic segmentation from abdominal CT scans may be of clinical importance. The current state-of-the-art method for edema segmentation using intensity priors is susceptible to false positives or under-segmentation errors.

Ru(II)-Catalyzed Skeletal Editing of Oxindole with Internal Alkyne To Synthesize C7-Alkylated Indole Derivatives.

A Ru(II)-catalyzed skeletal editing of oxindole scaffolds was established to afford C7-alkyl acetate indole derivatives using internal alkyne and alkyl alcohol. The developed method is simple, efficient, and straightforward. The reaction was extended to substrates having wide chemoselective profiles.

Subcutaneous edema segmentation on abdominal CT using multi-class labels and iterative annotation.

Purpose: Anasarca is a condition that results from organ dysfunctions, such as heart, kidney, or liver failure, characterized by the presence of edema throughout the body. The quantification of accumulated edema may have potential clinical benefits. This work focuses on accurately estimating the amount of edema non-invasively using abdominal CT scans, with minimal false positives.