Publications by authors named "S Bhadange"
Article Synopsis
- The parasite Leishmania causes Leishmaniasis by residing in macrophage vacuoles and manipulating host cell signaling pathways.
- The study finds that LmjMAPK4, a specific mitogen-activated protein kinase, is overexpressed in virulent L. major and affects macrophage responses by selectively interacting with certain MAPKs.
- Targeting LmjMAPK4 with a specific inhibitor can restore protective immune functions in infected mice, highlighting its potential as a drug target for treating Leishmaniasis.
The radioactive contamination has been reported frequently from agricultural lands and ground water. The main reason behind the radioactive pollution is unprotected mining of radioactive elements, unsafe discard of nuclear industrial waste, military applications, dumping of medically used radioisotopes, globally situated (>400) nuclear power plants and use of phosphate fertilizers in farming. Radionuclides are well known potent carcinogens that may cause the various types of cancers to human and animals due to the long exposure to radioactive contaminated sites.
View Article and Find Full Text PDFUnlabelled: Low-grade myofibroblastic sarcoma is a malignant tumor arising from myofibroblasts, which has only recently become clearly defined. It represents a rare entity developing in the soft tissues of the head and neck. About 20 cases have been reported in the oral cavity, especially in the tongue and bone, while gingiva as the primary site has been described only twice to date.
View Article and Find Full Text PDFThe pro-inflammatory IFNγ-STAT1 pathway and anti-inflammatory IL10-STAT3 pathway elicit cellular responses primarily utilizing their canonical STATs. However IL10 mediated STAT1 and IFNγ mediated STAT3 activation is also observed, suggesting crosstalk of these functionally opposing signaling pathways can potentially reshape the canonical dynamics both STATs and alter the expression of their target genes. Herein, we measured the dynamics of STATs in response to different doses of IL10 or IFNγ and in their co-stimulation and employed quantitative modeling to understand the regulatory mechanisms controlling signal responses in individual and co-simulation scenarios.
View Article and Find Full Text PDFAim: Assessment of root morphology, size, and amount of bone around tooth is essential before starting the orthodontic treatment. The present study aimed to assess the relationship between tooth dimensions with two gene variants of growth hormone (GH), namely rs6184 and rs6180.
Materials And Methods: This study was conducted on 218 subjects (males: 104, females: 114) requiring orthodontic treatment.