Publications by authors named "S Beziat"
PET Study of Microglial Activation in Kleine-Levin Syndrome.
Neurol Neuroimmunol Neuroinflamm
July 2024
Article Synopsis
- Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurring episodes of excessive sleepiness and cognitive/behavioral issues, potentially linked to inflammation, prompting a study on microglia activation using PET imaging.
- Researchers conducted PET scans on KLS patients and controls, focusing on specific brain regions to measure microglial activation and compare conditions during symptomatic and asymptomatic phases.
- The study found no significant differences in microglial activation between KLS patients and controls or between symptomatic and asymptomatic periods, suggesting a lack of neuroinflammation in KLS and indicating the need for further research on potential biomarkers.
Article Synopsis
- Narcolepsy type 1 (NT1) is linked to the loss of orexin-producing neurons in the hypothalamus, potentially due to an immune response, but past studies showed no inflammation during later stages of the disease.
- This research investigated microglia density in the hypothalamus and thalamus of NT1 patients using PET imaging, compared to control subjects, while also exploring relationships between microglial activity and disease factors like duration and severity.
- Results indicated no significant differences in microglial density between NT1 patients and controls in the hypothalamus and thalamus, but lower overall brain microglial activity was observed in NT1 patients, raising questions about the disease's immune mechanisms and its onset
Study Objectives: Narcolepsy type 2 (NT2) is an understudied central disorder of hypersomnolence sharing some similarities with narcolepsy type 1 and idiopathic hypersomnia (IH). We aimed: (1) to assess systematically the symptoms in patients with NT2, with self-reported questionnaires: Epworth Sleepiness Scale (ESS), Narcolepsy Severity Scale (NSS), IH Severity Scale (IHSS), and (2) to evaluate the responsiveness of these scales to treatment.
Methods: One hundred and nine patients with NT2 (31.
Symptoms of restless legs syndrome are relieved by movement. Whether a cognitive task decreases sensory discomfort remains understudied. We aimed to assess the frequency of patients with restless legs syndrome who report decreased sensory discomfort during cognitive activities, and quantify this decrease during a cognitive task.
View Article and Find Full Text PDFBackground And Objectives: To explore the first coronavirus disease 2019 (COVID-19) lockdown effect on sleep symptoms in patients with narcolepsy, idiopathic hypersomnia (IH), and restless legs syndrome (RLS).
Methods: Between March and May 2020, a sample of adult patients regularly followed up in a Reference Hospital Sleep Unit (299 with narcolepsy, 260 with IH, and 254 with RLS) was offered an online survey assessing their sleep-wake habits, daily activities, medication intake, and validated scales: International RLS Study Group questionnaire, Narcolepsy Severity Scale (NSS), IH Severity Scale (IHSS), Epworth Sleepiness Scale (ESS), Insomnia Severity Index, Beck Depression Inventory-II, and European Quality of Life (QoL) scale. The survey was proposed once, and the questions were answered for the prelockdown (recall of the month before the confinement) and the lockdown (time of study) periods.