Publications by authors named "S Bernini"
Background: Currently, the impact of drug therapies on neurodegenerative conditions is limited. Therefore, there is a strong clinical interest in non-pharmacological interventions aimed at preserving functionality, delaying disease progression, reducing disability, and improving quality of life for both patients and their caregivers. This longitudinal multicenter Randomized Controlled Trial (RCT) applies three innovative cognitive telerehabilitation (TR) methods to evaluate their impact on brain functional connectivity reconfigurations and on the overall level of cognitive and everyday functions.
View Article and Find Full Text PDFBackground: Neuropsychiatric symptoms (NPSs) are a distressful aspect of dementia and the knowledge of structural correlates of NPSs is limited. We aimed to identify associations of fronto-limbic circuit with specific NPSs in patients with various types of cognitive impairment.
Methods: Of 84 participants, 27 were diagnosed with mild cognitive impairment (MCI), 41 with Alzheimer's disease (AD) dementia and 16 with non-AD dementia.
Article Synopsis
- A study on older adults assessed the prevalence of polypharmacy (PP), potential drug-drug interactions (DDIs), and anticholinergic burden (ACB) and their effects on cognitive function, focusing on 636 participants aged around 73 years.
- About 27.2% of participants experienced PP, 42.3% faced potential DDIs, and 19% had significant ACB, with women being more affected by ACB than men.
- The research found that a higher ACB was linked to a 24% increased risk of mild cognitive impairment (MCI) and significantly poor executive function, urging clinicians to carefully manage anticholinergic prescriptions.
Data on the association of the Mediterranean diet (MD) with depressive symptoms in older people at high risk of depression are scarce. This study aimed to investigate the cross-sectional association of the adherence to the MD and its components with depressive symptoms in an Italian cohort of older men and women. A total of 325 men and 473 women aged 65–97 years (2019–2023) answered a 102-item semi-quantitative FFQ, which was used to calculate the Mediterranean diet score (MDS).
View Article and Find Full Text PDFObjectives: Despite extensive research, a clear understanding of the role of the interaction between lifestyle and socioeconomic status (SES) on cognitive health is still lacking. We investigated the joint association of socioeconomic factors in early to midlife and lifestyle in later life and Mild Cognitive Impairment (MCI).
Design: Observational cross-sectional study.