Publications by authors named "S Benloucif"
Article Synopsis
- * A study using Medicare claims analyzed the rate of ADRD diagnoses in older adults and found that the diagnosis rate varied significantly by hospital referral regions, with lower rates in certain demographic groups such as Black and Hispanic individuals, and those aged 66-74.
- * The findings suggest that where individuals live significantly affects their chances of receiving an ADRD diagnosis, highlighting the need for targeted efforts in areas with low diagnosis intensity to improve case identification.
Age-related changes in circadian rhythms may contribute to the sleep disruption observed in older adults. A reduction in responsiveness to photic stimuli in the circadian timing system has been hypothesized as a possible reason for the advanced circadian phase in older adults. This project compared phase-shifting responses to 2 h of broad-spectrum white light at moderate and high intensities in younger and older adults.
View Article and Find Full Text PDFStudy Objectives: To evaluate the effect of increasing the intensity and/or duration of exposure on light-induced changes in the timing of the circadian clock of humans.
Design: Multifactorial randomized controlled trial, between and within subject design
Setting: General Clinical Research Center (GCRC) of an academic medical center
Participants: 56 healthy young subjects (20-40 years of age)
Interventions: Research subjects were admitted for 2 independent stays of 4 nights/3 days for treatment with bright or dim-light (randomized order) at a time known to induce phase delays in circadian timing. The intensity and duration of the bright light were determined by random assignment to one of 9 treatment conditions (duration of 1, 2, or 3 hours at 2000, 4000, or 8000 lux).
Article Synopsis
- MT1 and MT2 melatonin receptors in CHO cells maintain sensitivity to melatonin re-challenge even after chronic exposure when microtubules are depolymerized, which typically leads to receptor desensitization.
- Microtubule depolymerization also enhances melatonin-induced PKC activity and GTP exchange on Gi proteins, indicating a potential role in modulating receptor activity.
- Experiments on Long Evans rats show that disrupting microtubules in the suprachiasmatic nucleus increases the effectiveness of melatonin in phase-shifting circadian rhythms, suggesting a link between microtubule dynamics and circadian regulation.
Study Objectives: To provide guidelines for collecting and analyzing urinary, salivary, and plasma melatonin, thereby assisting clinicians and researchers in determining which method of measuring melatonin is most appropriate for their particular needs and facilitating the comparison of data between laboratories.
Methods: A modified RAND process was utilized to derive recommendations for methods of measuring melatonin in humans.
Results: Consensus-based guidelines are presented for collecting and analyzing melatonin for studies that are conducted in the natural living environment, the clinical setting, and in-patient research facilities under controlled conditions.