Publications by authors named "S Beath"
Background: Bench liver reduction, with or without intestinal length reduction (LR) (coupled with delayed closure and abdominal wall prostheses), has been a strategy adopted by our program for small children due to the limited availability of size-matched donors. This report describes the short, medium, and long-term outcomes of this graft reduction strategy.
Methods: A single-center, retrospective analysis of children that underwent intestinal transplantation (April 1993 to December 2020) was performed.
Deciding which patients would benefit from intestinal transplantation (IT) remains an ethical/clinical dilemma. New criteria* were proposed in 2015: ≥2 intensive care unit (ICU) admissions, loss of ≥3 central venous catheter (CVC) sites, and persistently elevated conjugated bilirubin (CB ≥ 75 μmol/L) despite 6 weeks of lipid modification strategies. We performed a retrospective, international, multicenter validation study of 443 children (61% male, median gestational age 34 weeks [IQR 29-37]), diagnosed with IF between 2010 and 2015.
View Article and Find Full Text PDFWe evaluated long term outcomes in infants born between 1992 and 2002 with cholestatic liver disease (CLD) who underwent successful liver transplantation (LT). A total of 160 children with CLD were identified: 68 had developmental assessments before and after LT of whom 32 were excluded because they were followed up elsewhere; 16/36 consented to complete measures of IQ, anxiety, depression, health related quality of life (HRQoL), and a habits/employment survey. Illness severity and developmental attainment prior to LT were comparable with the 32 excluded and 20 patients who declined to take part.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined outcomes for 443 children with intestinal failure across six pediatric programs from 2010 to 2015, focusing on enteral autonomy, transplantation rates, and mortality.
- - Main causes of intestinal failure included short bowel syndrome (85%), with cumulative rates showing 53% achieving enteral autonomy, 17% undergoing transplantation, and 11% dying within six years.
- - While mortality and transplantation rates have improved, the ability of children to achieve enteral autonomy remains unchanged, indicating a need for new strategies to enhance patient outcomes.