Publications by authors named "S Bayle"
Article Synopsis
- - The study focuses on mapping and analyzing areas vulnerable to malaria in Northern Plateau State, Nigeria, as a crucial step for planning interventions and managing resources effectively against malaria infections.
- - Using environmental risk factors, researchers identified high-risk areas covering over 4,000 km², with 60% of the region exhibiting a significant risk of malaria transmission, particularly near certain local government areas.
- - The resulting malaria risk map demonstrated high predictive accuracy and sensitivity, providing policymakers with valuable insights for targeted malaria control measures and better understanding of the disease's dynamics.
Article Synopsis
- Neurofibromatosis type 2 (NF2) is a rare condition leading to tumors like vestibular schwannomas and meningiomas, and currently lacks FDA approved medication.* -
- Previous research shows that BET inhibition can slow the growth of NF2-related cells, and this study investigates whether combining both BET and FAK inhibition could enhance these effects.* -
- Results indicate that this combination effectively halts the growth of NF2-null cells by disrupting their cell cycle and significantly downregulating FAK1, suggesting a promising new treatment approach for NF2-related tumors.*
Although hydrogen peroxide (HO) has been highly used in nuclear chemistry for more than 75 years, the preparation and literature description of tetravalent actinide peroxides remain surprisingly scarce. A new insight is given in this topic through the synthesis and thorough structural characterization of a new peroxo compound of Pu(IV).
View Article and Find Full Text PDFThe UNC-51-like kinase-1 (ULK1) is one of the central upstream regulators of the autophagy pathway, represents a key target for the development of molecular probes to abrogate autophagy and explore potential therapeutic avenues. Here we report the discovery, structure-activity and structure-property relationships of selective, potent, and cell-active ULK1/2 inhibitors based on a 7-azaindole scaffold. Using structure-based drug design, we have developed a series of analogs with excellent binding affinity and biochemical activity against ULK1/2 (IC < 25 nM).
View Article and Find Full Text PDFIn this article, the speciation and behavior of anthropogenic metallic uranium deposited on natural soil are approached by combining EXAFS (extended X-ray absorption fine structure) and TRLFS (time-resolved laser-induced fluorescence spectroscopy). First, uranium (uranyl) speciation was determined along the vertical profile of the soil and bedrock by linear combination fitting of the EXAFS spectra. It shows that uranium migration is strongly limited by the sorption reaction onto soil and rock constituents, mainly mineral carbonates and organic matter.
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