Publications by authors named "S Batabyal"
A range of NMR techniques, including diffusion ordered spectroscopy (DOSY) were used to characterise complex micelles formed by the anti-microbial cationic surfactant cetylpyridium chloride and to quantify the degree of interaction between cetylpyridium chloride and hydroxyethyl cellulose in a variety of commercially relevant formulations as a model for the disk retention assay. This NMR-derived binding information was then compared with the results of formulation analysis by traditional disk retention assay (DRA) and anti-microbial activity assays to assess the suitability of these NMR techniques for the rapid identification of formulation components that could augment or retard antimicrobial activity DRA. NMR showed a strong ability to predict anti-microbial activity for a diverse range of formulations containing cetylpyridinium chloride (CPC).
View Article and Find Full Text PDFLeber congenital amaurosis (LCA) is a sight-threatening inherited retinal disorder (IRD) caused by numerous genetic mutations. Multi-characteristic opsin (MCO)-based optogenetic therapy allows the recruitment of residual cells of the retina in LCA for alternative vision transduction while being mutation-agnostic. Using mice, we investigated the efficacy of an adeno-associated virus2 (AAV2)-transduced ambient light-activatable MCO (MCO-010) containing a metabotropic glutamate receptor-6 bipolar cell-specific promoter/enhancer.
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- The study evaluated the impact of a viral vector-delivered multi-characteristic opsin (MCO-010) on vision in two mouse models of retinitis pigmentosa (rp1 and rp10), focusing on both structural and functional outcomes.
- MCO-010 was injected into the eyes of the mice, resulting in successful transduction of about 80% of bipolar cells without affecting retinal thickness, while control mice showed thinning.
- The treatment improved behavior and visual response in the mice without causing toxicity under challenging conditions, suggesting it could help slow retinal degeneration.
Article Synopsis
- This study presents a novel approach to recycle spent graphite from lithium-ion battery waste to create graphene oxide (GO) for use in zinc-ion batteries (AZIB).
- The synthesized GO from spent graphite (SG-GO) demonstrates superior electrochemical performance, achieving a charge capacity of 270 mAh/g compared to 198 mAh/g for commercial graphite-derived GO at the same current density.
- Long-term tests show SG-GO maintains 77.3% capacity retention after 1000 cycles, with optimal performance observed using a 3 M ZnSO electrolyte for improved zinc ion storage.
Granulomatous inflammation represents a unique pattern of chronic inflammation observed in a restricted form of infectious and certain non-infectious diseases. The formation of granulomas typically involves immune responses. Granulomatous disorders encompass a broad spectrum of conditions that share the common histological feature of granuloma formation.
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