Use of benzodiazepine and Z-drugs and mortality in older adults after myocardial infarction.

Background: The adverse cardiovascular effects of benzodiazepines and Z-drugs (jointly referred as BZDRs) have been of concern. Yet, little is known about the use of BZDRs in relation to mortality risk among older adults with myocardial infarction history (post-MI).

Methods: This study is a secondary analysis of the Alpha Omega Cohort study, comprising post-MI patients aged 40-60 years.

An Optimized NMR Stripline for Sensitive Supercritical Fluid Chromatography-Nuclear Magnetic Resonance of Microliter Sample Volumes.

To optimize sensitivity, there has been an increasing interest in the miniaturization of NMR detectors. In our lab, a stripline NMR detector has been developed, which provides high resolution and is scalable to a large range of sample volumes. These features make it an ideal detector for hyphenated techniques.

Rapid-melt DNP for multidimensional and heteronuclear high-field NMR experiments.

Low sensitivity is the main limitation of NMR for efficient chemical analysis of mass-limited samples. Hyperpolarization techniques such as Dynamic Nuclear Polarization (DNP) have greatly improved the efficiency of NMR experiments. In this manuscript, we demonstrate a 400 MHz rapid-melt DNP setup.

Characterising polar compounds using supercritical fluid chromatography-nuclear magnetic resonance spectroscopy (SFC-NMR).

To detect and characterise compounds in complex matrices, it is often necessary to separate the compound of interest from the matrix before analysis. In our previous work, we have developed the coupling of supercritical fluid chromatography (SFC) with nuclear magnetic resonance (NMR) spectroscopy for the analysis of nonpolar samples [Van Zelst et al., Anal.

ssNake: A cross-platform open-source NMR data processing and fitting application.

For solid-state NMR or for unconventional experiments only a very limited number of modern processing and simulation software packages are available. For this reason, we have developed ssNake, an NMR processing program which provides both interactive and script-based processing tools. ssNake is aimed at solid-state NMR experiments, but can also be used for liquid-state experiments.