Publications by authors named "S Barrena"
Article Synopsis
- Tumor deposits (TDs) are associated with poorer outcomes in colorectal cancer (CRC) patients, leading to lower cancer-related survival (CRS) and shorter time-to-recurrence (TTR) compared to those without TDs.
- In a study with 1,426 CRC patients, those with TDs showed significantly reduced CRS (42% vs. 82%) and TTR (34% vs. 79%) over five years.
- The findings suggest that incorporating TDs into the TNM classification system could help better identify high-risk groups and improve prognostic evaluations.
Purpose: Natural killer (NK) cells are traditionally identified by flow cytometry using a combination of markers (CD16/CD56/CD3), because a specific NK-cell marker is still missing. Here we investigated the utility of CD314, CD335 and NKp80, compared to CD16/CD56/CD3, for more robust identification of NK-cells in human blood, for diagnostic purposes.
Methods: A total of 156 peripheral blood (PB) samples collected from healthy donors (HD) and patients with diseases frequently associated with loss/downregulation of classical NK-cell markers were immunophenotyped following EuroFlow protocols, aimed at comparing the staining profile of total blood NK-cells for CD314, CD335 and NKp80, and the performance of distinct marker combinations for their accurate identification.
Presence of minimal residual disease (MRD), detected by flow cytometry, is an important prognostic biomarker in the management of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, data-analysis remains mainly expert-dependent. In this study, we designed and validated an Automated Gating & Identification (AGI) tool for MRD analysis in BCP-ALL patients using the two tubes of the EuroFlow 8-color MRD panel.
View Article and Find Full Text PDFAim: Sarcopenia is associated with poor prognosis in adult oncologic patients, with little evidence of this association in pediatric population, including hepatoblastoma.
Methods: Retrospective study in patients with hepatoblastoma, divided into those with or without sarcopenia. Sarcopenia was assessed by measuring psoas muscle area (PMA) at L4-L5 level on the CT/MR and defined as z-score values ≤ 2.
Objective: To report a 15-y, single-center experience in the management and outcomes of ileocolic intussusception (ICI) episodes.
Methods: A retrospective study was performed in patients with ICI episodes, who were treated at a single quaternary referral center from 2005 to 2019. Data evaluated included patient demographics, clinical presentation, treatment modalities, hospital stay, complications, and outcomes.