Publications by authors named "S Baredes"
Objectives: Changing location of postoperative radiotherapy (PORT) after treatment at a high-volume facility (HVF) is associated with worse survival in various head and neck cancers. Our study investigates this relationship in salivary gland cancer (SGC).
Methods: The 2004-2016 National Cancer Database was queried for all cases of adult SGC treated with surgery and PORT with or without adjuvant chemotherapy.
Article Synopsis
- Maackia amurensis lectins, specifically M. amurensis seed lectin (MASL), bind to sialic acid residues on proteins, showing potential to reduce inflammation in arthritic cells and inhibit tumor growth and movement.
- The study characterized MASL into two groups based on its ability to form dimers, with MASL having unique isoforms and glycosylation sites that significantly impact its function and interaction with the podoplanin (PDPN) receptor.
- Results indicate that MASL exhibits strong binding to PDPN and can effectively inhibit the growth and motility of oral squamous cell carcinoma (OSCC) cells, highlighting its potential use as an antic
Radiation treatment plays a mainstream role in the management of head and neck squamous cell carcinomas (HNSCCs). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathologic fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCCs.
View Article and Find Full Text PDFRadiation treatment plays a mainstream role in the management of head and neck cancers (HNSCC). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathological fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCC.
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