Zebrafish models of human-duplicated reveal novel functions in microglia and visual system development.

The expansion of the human family, resulting in a human-specific paralog likely contributed to altered evolutionary brain features. The introduction of in mouse models is associated with changes in cortical neuronal migration, axon guidance, synaptogenesis, and sensory-task performance. Truncated SRGAP2C heterodimerizes with the full-length ancestral gene product SRGAP2A and antagonizes its functions.

Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish model.

Dravet syndrome is a severe genetic epilepsy primarily caused by mutations in a voltage-activated sodium channel gene (). Patients face life-threatening seizures that are largely resistant to available anti-seizure medications. Preclinical Dravet syndrome animal models are a valuable tool to identify candidate anti-seizure medications for these patients.

Host brain environmental influences on transplanted medial ganglionic eminence progenitors.

Interneuron progenitor transplantation can ameliorate disease symptoms in a variety of neurological disorders. The strategy is based on transplantation of embryonic medial ganglionic eminence (MGE) progenitors. Elucidating how host brain environment influences the integration of interneuron progenitors is critical for optimizing this strategy across different disease states.

Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish model.

Dravet syndrome (DS) is a severe genetic epilepsy primarily caused by mutations in a voltage-activated sodium channel gene (SCN1A). Patients face life-threatening seizures that are largely resistant to available anti-seizure medications (ASM). Preclinical DS animal models are a valuable tool to identify candidate ASMs for these patients.

Estimating the effectiveness of electric vehicles braking when determining the circumstances of a traffic accident.

In the vast majority of cases, the braking process is used to prevent traffic accidents. The effectiveness of this process depends on the design and functionality of vehicle braking systems (presence of anti-lock braking system, emergency braking system, preventive safety systems, etc.) and is limited by the amount of frictional forces in contact of tires with the road.