Publications by authors named "S Bannier"
Objective: Asleep deep brain stimulation (DBS) for Parkinson's disease (PD) is being performed more frequently; however, motor outcomes and safety of asleep DBS have never been assessed in a prospective randomized trial.
Methods: We conducted a prospective, randomized, noncomparative trial to assess the motor outcomes of asleep DBS. Leads were implanted in the subthalamic nucleus (STN) according to probabilistic stereotactic coordinates with a surgical robot under O-arm© imaging guidance under either general anesthesia without microelectrode recordings (MER) (20 patients, asleep group) or local anesthesia with MER and clinical testing (9 patients, awake group).
Increased diagnostic yield in complex dystonia through exome sequencing.
Parkinsonism Relat Disord
May 2020
Article Synopsis
- A study investigated the effectiveness of Whole Exome Sequencing (WES) to identify genetic causes in patients with early-onset or familial dystonia, where traditional gene panel sequencing had low diagnostic rates.
- The research involved 32 patients and found that WES identified causative genetic variants in 11 patients from 9 families, resulting in a 34.4% overall diagnostic rate, with higher success in complex dystonia cases.
- The findings indicate that WES could significantly enhance diagnostic capabilities beyond gene panel sequencing, particularly for patients with associated intellectual disabilities, suggesting further research is needed to explore links between dystonia and other neurodevelopmental disorders.
Prevalence and phenomenology of olfactory hallucinations in Parkinson's disease.
J Neurol Neurosurg Psychiatry
October 2012
Background: Although visual hallucinations in Parkinson's disease (PD) have been described in several major studies, little is known about olfactory hallucinations (OHs).
Methods: The authors performed a detailed analysis of OHs in a cohort of 87 Parkinsonian patients to estimate the prevalence of OHs and describe their phenomenology. They also evaluated smelling abilities in terms of detection and identification.
Parkinson's disease is a neurodegenerative disorder clinically characterized by motor impairments (tremor, bradykinesia, rigidity and postural instability) associated or not with non-motor complications (cognitive disorders, dysautonomia). Most of patients loose weight during evolution of their disease. Dysregulations of hypothalamus, which is considered as the regulatory center of satiety and energy metabolism, could play a major role in this phenomenon.
View Article and Find Full Text PDFOverweight after deep brain stimulation of the subthalamic nucleus in Parkinson disease: long term follow-up.
J Neurol Neurosurg Psychiatry
May 2009
Objective: To assess the occurrence of weight gain in patients with Parkinson's disease, with an average 16 months of follow-up after subthalamic nucleus deep brain stimulation.
Methods: We used dual x ray absorptiometry to evaluate changes in body weight and body composition in 22 patients with Parkinson's disease (15 men and seven women) before surgery, 3 months after surgery and on average 16 months after surgery.
Results: No patient was underweight before surgery and 50% were overweight.