Publications by authors named "S Balasubramanya"

Introduction: This study presents the authors' experience over 14 years of performing restorative procto-colectomy with ileal pouch anal anastomosis (IPAA). The aim was to study the long-term quality of life outcomes and analyse the predictors of pouch function as well as physical and mental wellbeing.

Methods: This is a single-centre retrospective study conducted in a specialised colorectal surgery unit in the UK.

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Article Synopsis
  • Metastatic urothelial carcinoma, a type of bladder cancer, is tough to cure with current treatments.
  • Many mutations affect how genes are turned on and off, especially in a gene called ARID1A, which is missing or broken in about 20% of these cancers.
  • Research has shown that cancers with ARID1A mutations respond better to drugs that block another gene called EZH2, especially when used together with PI3K inhibitors.
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Aim: Young colorectal cancer (CRC) patients are reported to have more aggressive disease, an advanced stage at diagnosis and conflicting survival outcomes. The aim of this study was to analyse the demographics, clinicopathological features and prognosis of young CRC at a population-based level in England.

Method: This is a retrospective review of all CRC patients using data from Public Health England collated from regional cancer registries in England between 2010 and 2014.

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