Publications by authors named "S Baize"
Article Synopsis
- - The study explores how Lassa fever develops and the factors that determine whether it results in a mild or severe illness, using a monkey model to replicate different disease outcomes.
- - It finds that lymphoid organs are key early sites for the replication of the Lassa virus, which can enter through lymph node structures regardless of whether the infection is fatal or not.
- - The severity of the disease correlates with how the virus spreads; in nonfatal cases, it largely stays within lymphoid tissues, while fatal outcomes see the virus invade multiple organs, triggering a strong immune inflammatory response.
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins. All Mammarenavirus identified to date share a common dependency on myristoylation: the addition of the C14 myristic acid on the N-terminal G2 residue on two of their proteins.
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- - High seroreactivities to Ebola (EBOV) and Sudan (SUDV) orthoebolavirus antigens were found in rural populations of Cameroon, particularly among Pygmies, despite no reported outbreaks.
- - The study did not find a direct link between the risk of NHP (nonhuman primates) bites and seroreactivity, but indicated that exposure may vary among different ethnic groups.
- - These findings suggest a possible silent circulation of orthoebolaviruses or other unknown filoviruses in forested regions, emphasizing the need for increased surveillance and research in these areas.
Nipah virus (NiV) has been recently ranked by the World Health Organization as being among the top eight emerging pathogens likely to cause major epidemics, whereas no therapeutics or vaccines have yet been approved. We report a method to deliver immunogenic epitopes from NiV through the targeting of the CD40 receptor of antigen-presenting cells by fusing a selected humanized anti-CD40 monoclonal antibody to the Nipah glycoprotein with conserved NiV fusion and nucleocapsid peptides. In the African green monkey model, CD40.
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- Crimean-Congo haemorrhagic fever (CCHF) is a serious viral disease transmitted from animals to humans, characterized by fever and bleeding symptoms.
- The virus has been found in ticks in Spain and antibodies in livestock in Corsica, raising concerns about its presence in France.
- During 2022-2023, 155 ticks carrying the Crimean-Congo haemorrhagic fever virus (CCHFV) were identified in southern France from horses and cattle.