Publications by authors named "S Bain"
Introduction: Heterotopic ossification (HO) occurs following orthopedic trauma, spinal cord injuries, brain trauma and limb amputations. Once symptomatic, HO causes pain, limited mobility and decreased quality of life. Current treatments are limited and have significant complications with high recurrence rates, underscoring the need for improved therapeutic interventions.
View Article and Find Full Text PDFIntroduction: The high risk of cardiovascular events in people with type 2 diabetes increases with age. The cardiovascular effects of once-weekly subcutaneous and once-daily oral semaglutide versus placebo in people with type 2 diabetes at high cardiovascular risk were investigated in the SUSTAIN 6 and PIONEER 6 cardiovascular outcomes trials, respectively. It is unknown whether the effects of semaglutide are age dependent.
View Article and Find Full Text PDFCurrent management of chronic kidney disease in type-2 diabetes-A tiered approach: An overview of the joint Association of British Clinical Diabetologists and UK Kidney association (ABCD-UKKA) guidelines.
Diabet Med
October 2024
Article Synopsis
- A significant number of people with diabetes develop chronic kidney disease (CKD), which often leads to end-stage kidney disease (ESKD) and is highly associated with cardiovascular disease (CVD) mortality.
- Managing modifiable risk factors, such as hyperglycemia and hypertension, along with treating dyslipidemia is vital for patients with type 2 diabetes and CKD to reduce the risk of CVD.
- Recent clinical trials demonstrate that medications like SGLT-2 inhibitors and GLP-1 receptor agonists can help protect kidney function in these patients, informing updated clinical practice guidelines for healthcare professionals.
Article Synopsis
- Researchers monitored nine cyclists using glucose sensors during a training camp to analyze their interstitial glucose (iG) levels across different times of the day.
- The study found that on average, cyclists spent 93% of the time in the normal glucose range, 8% below, and 3% above that range, with daytime glucose levels being significantly higher than nighttime levels.
- The findings suggest that lower glucose levels during the night could have implications for non-diabetics and highlight the need for further research on glucose management in athletes.
Article Synopsis
- Globally, while people are living longer, many experience a decline in health due to age-related diseases, highlighting the need for better classification systems to address these issues.
- A consensus meeting with 150 experts established criteria for identifying ageing-related pathologies, requiring a 70% agreement for approval among participants.
- The agreed criteria focus on conditions that progress with age, contribute to functional decline, and are backed by human studies, setting a foundation for future classification and staging efforts.