Publications by authors named "S Bagnasco"
Background: Interstitial fibrosis in lupus nephritis (LN) is often infiltrated by immune cells but typically regarded as nonspecific "scar reaction." This study aimed to investigate the relationship between inflammatory fibrosis and kidney disease progression in LN.
Methods: Interstitial fibrosis and tubular atrophy (IFTA) were scored in 124 LN kidney biopsies.
Background: The outcome of kidney transplant recipients with a history of complement-mediated thrombotic microangiopathy (cTMA) and those who develop post-transplant de novo TMA (dnTMA) is largely unknown.
Methods: We retrospectively studied all kidney transplant recipients with end-stage kidney disease secondary to cTMA and those who developed dnTMA, between Jan 2000 and Dec 2020 in our center.
Results: We identified 134 patients, 22 with cTMA and 112 had dnTMA.
Article Synopsis
- The number of kidney transplant recipients has significantly increased over the past 20 years due to advancements in medical technology.
- Nephrologists play a crucial role in providing ongoing care for transplant patients, focusing on long-term health management.
- It's essential for nephrologists to have an in-depth understanding of key issues like immunosuppression, potential infections, and factors leading to kidney graft dysfunction.
Article Synopsis
- - The optimization of electron microscopy (EM) tissue processing protocols is urgent due to the rising number of renal biopsies needing EM for accurate diagnoses, with traditional methods taking 48-52 hours compared to a faster 8-hour microwave-based method.
- - Concerns exist about the quality of the fast-processing EM (FEM) potentially affecting diagnoses; however, this study provides evidence that FEM produces comparably high-resolution images to the conventional EM (CEM).
- - Both prospective and retrospective analyses showed no significant differences between FEM and CEM in terms of image quality and structural features of kidney tissues, indicating that FEM can be a reliable alternative for quicker diagnoses.
Article Synopsis
- Kidney transplantation from HIV-positive donors to HIV-positive recipients is a growing practice, initiated under a 2016 U.S. law, and is currently being evaluated for broader clinical implementation.
- An observational study involving 408 candidates at 26 U.S. centers assessed the safety and health outcomes of kidney transplants from both HIV-positive and HIV-negative donors to HIV-positive recipients, finding no significant difference in major health risks between the two donor groups.
- Results indicated similar long-term survival rates, graft success, and complication rates across both groups, although recipients of kidneys from HIV-positive donors showed a higher incidence of HIV breakthrough infections.