Publications by authors named "S Bagby"
Interactions between microbiomes and metabolites play crucial roles in the environment, yet how these interactions drive greenhouse gas emissions during ecosystem changes remains unclear. Here we analysed microbial and metabolite composition across a permafrost thaw gradient in Stordalen Mire, Sweden, using paired genome-resolved metagenomics and high-resolution Fourier transform ion cyclotron resonance mass spectrometry guided by principles from community assembly theory to test whether microorganisms and metabolites show concordant responses to changing drivers. Our analysis revealed divergence between the inferred microbial versus metabolite assembly processes, suggesting distinct responses to the same selective pressures.
View Article and Find Full Text PDFCancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth and survival. However, the mechanisms underlying the formation of these pathological networks remain poorly understood. Through a pan-cancer epigenomic analysis, we found that primate-specific endogenous retroviruses (ERVs) are a rich source of enhancers displaying cancer-specific activity.
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- Patients with acral and mucosal melanomas (A/M) have fewer treatment options and worse outcomes compared to those with cutaneous melanomas.
- The study analyzed 156 melanoma cases and discovered new genomic alterations in A/M melanomas that could be targeted for treatment.
- Key findings included unique alterations specific to A/M melanomas that respond to certain inhibitors, suggesting a need for tailored clinical testing and treatment strategies.
Optical microcavities, particularly whispering gallery mode (WGM) microcavities enhanced by plasmonic nanorods, are emerging as powerful platforms for single-molecule sensing. However, the impact of optical forces from the plasmonic near field on analyte molecules is inadequately understood. Using a standard optoplasmonic WGM single-molecule sensor to monitor two enzymes, both of which undergo an open-to-closed-to-open conformational transition, the work done on an enzyme by the WGM sensor as atoms of the enzyme move through the electric field gradient of the plasmonic hotspot during conformational change has been quantified.
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- * The study involved 50 patients who had not responded to at least two previous treatments, resulting in an objective response rate (ORR) of 12%, which was statistically better than historical data.
- * While the combination treatment showed a high disease control rate and acceptable side effects, it did not achieve the primary goal of improving ORR compared to historical controls.