Publications by authors named "S Baechler"

Article Synopsis
  • High-fat diets contribute significantly to metabolic dysfunctions like metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH), with mitochondria implicated in their development.
  • The study investigates the role of mitochondrial topoisomerase I (Top1MT) by using mice that lack this enzyme, revealing that these mice are more susceptible to severe MASH after being fed a high-fat diet for 16 weeks.
  • Findings show that Top1MT deficiency leads to severe liver issues, mitochondrial dysfunction, increased reactive oxygen species production, and enhanced hepatic inflammation, underscoring its critical role in maintaining liver cell health and preventing MASH.
View Article and Find Full Text PDF

From the beginnings of Silk Road in 2011, anonymous online marketplaces have continued to grow despite the best efforts of law enforcement. While these ever-present marketplaces remain flooded with illicit drugs and related paraphernalia, the sale and distribution of fraudulent identity documents remains a persistent problem, with these items consistently appearing for sale on both the open and dark web. While fraudulent Australian documents are some of the most popular products for sale, there is still much that is unknown about the Australian criminal market and its place within anonymous online marketplaces.

View Article and Find Full Text PDF

The serial character of document fraud and its connection to organised crime groups who produce, sell and/or use fraudulent documents is a challenge for security and crime fighting. As a response, the added value of forensic intelligence is increasingly recognised. Using a forensic profiling method and a dedicated system deployed in Switzerland, document examiners can detect series (i.

View Article and Find Full Text PDF

Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells. Combination of the TOP1 inhibitor irinotecan or its bioactive metabolite SN38 with the NEDD8-activating enzyme inhibitor pevonedistat exhibits synergy in CRC patient-derived organoids and xenografts.

View Article and Find Full Text PDF

Over the years, forensic science has primarily positioned itself as a service provider for the criminal justice system, following the dominant and traditional reactive law enforcement model. Unfortunately, this focus has limited its capacity to provide knowledge about crime systems and to support other forms of policing styles through forensic intelligence. Although forensic intelligence research has steadily developed over the last few years, it is rarely covered in the core of academic teaching and research programs.

View Article and Find Full Text PDF