Publications by authors named "S Baboo"
The GPCR-like protein Smoothened (Smo) plays a pivotal role in the Hedgehog (Hh) pathway. To initiate Hh signaling, active Smo binds to and inhibits the catalytic subunit of PKA in the primary cilium, a process facilitated by G protein-coupled receptor kinase 2 (Grk2). However, the precise regulatory mechanisms underlying this process, as well as the events preceding and following Smo activation, remain poorly understood.
View Article and Find Full Text PDFEnterotoxigenic Escherichia coli (ETEC) cause hundreds of millions of cases of infectious diarrhea annually, predominantly in children from low-middle income regions. Notably, in children, as well as volunteers challenged with ETEC, diarrheal severity is significantly increased in blood group A (bgA) individuals. EtpA, is a secreted glycoprotein adhesin that functions as a blood group A lectin to promote critical interactions between ETEC and blood group A glycans on intestinal epithelia for effective bacterial adhesion and toxin delivery.
View Article and Find Full Text PDFArticle Synopsis
- - The HIV-1 envelope glycoprotein (Env) is crucial for the virus's ability to infect cells, requiring a specific cleavage process for its subunits to function in viral entry; a new method aims to enhance immunization strategies against HIV by genetically expressing a stable Env trimer on cell surfaces.
- - Researchers developed a 'native flexibly linked' (NFL) construct to simplify the expression of these HIV Env trimers without needing cleavage, ensuring they retain the right structure (native-like conformation) and can effectively stimulate the immune response.
- - The study shows that immunizing rabbits with mRNA lipid nanoparticles containing these membrane-bound stabilized Env trimers elicited strong neutralizing antibody responses, indicating potential for this genetic